Venous thromboembolism (VTE) is a serious medical condition associated with significant
morbidity and mortality, and an incidence that is expected to double in the next forty years …

A large body of evidence suggests that not only direct anticoagulant effects but also major
bleeding events and stroke prevention depend on plasma concentrations of direct oral …

Importance Non–vitamin K oral anticoagulants (NOACs) are commonly prescribed with other
medications that share metabolic pathways that may increase major bleeding risk. Objective …

Atrial fibrillation (AF) is the most common sustained arrhythmia, causing a 2-fold increase in
mortality and a 5-fold increase in stroke. The Asian population is rapidly aging, and in 2050 …

Essentials• Rivaroxaban and dabigatran are substrates of the P‐glycoprotein (P‐gp)
encoded by the ABCB1 gene.• We tested the effect of ABCB1 polymorphisms and of a P‐gp …

Vitamin K antagonists (VKAs) such as warfarin are the most commonly prescribed oral
anticoagulants worldwide. However, factors affecting the pharmacokinetics of VKAs, such as …

A microdose cocktail containing midazolam, dabigatran etexilate, pitavastatin, rosuvastatin,
and atorvastatin has been established to allow simultaneous assessment of a perpetrator …

Importance Clarithromycin is a commonly prescribed antibiotic associated with higher levels
of direct oral anticoagulants (DOACs) in the blood, with the potential to increase the risk of …

Ertugliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), is approved in
the US, EU, and other regions for the treatment of adults with type 2 diabetes mellitus …

Compared with warfarin, the direct-acting oral anticoagulants (DOAC) have fewer
pharmacokinetic drug interactions. However, significant drug interactions do exist with …