[HTML][HTML] Myeloid DNA methyltransferase3b deficiency aggravates pulmonary fibrosis by enhancing profibrotic macrophage activation
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and severe disease
characterized by excessive matrix deposition in the lungs. Macrophages play crucial roles in …
characterized by excessive matrix deposition in the lungs. Macrophages play crucial roles in …
[HTML][HTML] Role of myeloid tet methylcytosine dioxygenase 2 in pulmonary and peritoneal inflammation induced by lipopolysaccharide and peritonitis induced by …
W Qin, X Brands, H Matsumoto, JM Butler, C van't Veer… - Cells, 2021 - mdpi.com
Tet methylcytosine dioxygenase 2 (Tet2) mediates demethylation of DNA. We here sought to
determine the expression and function of Tet2 in macrophages upon exposure to …
determine the expression and function of Tet2 in macrophages upon exposure to …
[HTML][HTML] Critical role of Lkb1 in the maintenance of alveolar macrophage self-renewal and immune homeostasis
Q Wang, S Chen, T Li, Q Yang, J Liu, Y Tao… - Frontiers in …, 2021 - frontiersin.org
Alveolar macrophages (AMs) are pivotal for maintaining lung immune homeostasis. We
demonstrated that deletion of liver kinase b1 (Lkb1) in CD11c+ cells led to greatly reduced …
demonstrated that deletion of liver kinase b1 (Lkb1) in CD11c+ cells led to greatly reduced …
Hypoxia‐Inducible Factor‐1α in Macrophages, but Not in Neutrophils, Is Important for Host Defense during Klebsiella pneumoniae‐Induced Pneumosepsis
NA Otto, L Pereverzeva, V Leopold… - Mediators of …, 2021 - Wiley Online Library
Hypoxia‐inducible factor‐(HIF‐) 1α has been implicated in the ability of cells to adapt to
alterations in oxygen levels. Bacterial stimuli can induce HIF1α in immune cells, including …
alterations in oxygen levels. Bacterial stimuli can induce HIF1α in immune cells, including …
Intrapulmonary treatment with a novel tlr4 agonist confers protection against Klebsiella Pneumonia
A Hernandez, J Zhou, JK Bohannon, MA McBride… - Shock, 2022 - journals.lww.com
Objectives: Nosocomial pneumonia is a common complication in critically ill patients. The
goal of this study was to examine the efficacy of the Toll-like receptor 4 agonist 3-deacyl …
goal of this study was to examine the efficacy of the Toll-like receptor 4 agonist 3-deacyl …
Role of Hypoxia-inducible factor 1α in host defense during pneumococcal pneumonia
L Pereverzeva, NA Otto, H Peters-Sengers… - Pathogens and …, 2023 - academic.oup.com
Abstract Hypoxia-inducible factor (HIF) 1α is a transcription factor involved in cellular
metabolism and regulation of immune cell effector functions. Here, we studied the role of …
metabolism and regulation of immune cell effector functions. Here, we studied the role of …
[HTML][HTML] Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection
W Qin, X Brands, C Van't Veer, A F. de Vos… - PLoS …, 2021 - journals.plos.org
DNA methyltransferase (Dnmt) 3b mediates de novo DNA methylation and modulation of
Dnmt3b in respiratory epithelial cells has been shown to affect the expression of multiple …
Dnmt3b in respiratory epithelial cells has been shown to affect the expression of multiple …
[HTML][HTML] Identification of the transgene integration site and host genome changes in MRP8-Cre/ires-EGFP transgenic mice by targeted locus amplification
The MRP8-Cre-ires/EGFP transgenic mouse (Mrp8creTg, on C57BL/6J genetic background)
is popular in immunological and hematological research for specifically expressing Cre …
is popular in immunological and hematological research for specifically expressing Cre …
[HTML][HTML] Metabolic Effects of Selective Deletion of Group VIA Phospholipase A2 from Macrophages or Pancreatic Islet Beta-Cells
J Turk, H Song, M Wohltmann, C Frankfater, X Lei… - Biomolecules, 2020 - mdpi.com
To examine the role of group VIA phospholipase A2 (iPLA2β) in specific cell lineages in
insulin secretion and insulin action, we prepared mice with a selective iPLA2β deficiency in …
insulin secretion and insulin action, we prepared mice with a selective iPLA2β deficiency in …
[HTML][HTML] Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae
L Pereverzeva, NA Otto, JJTH Roelofs, AF de Vos… - Respiratory …, 2022 - Springer
Abstract Background Liver kinase B1 (Lkb1, gene name Stk11) functions as a tumor
suppressor in cancer. Myeloid cell Lkb1 potentiates lung inflammation induced by the Gram …
suppressor in cancer. Myeloid cell Lkb1 potentiates lung inflammation induced by the Gram …