The kidney consists of numerous cell types organized into the nephron, which is the basic
functional unit of the kidney. Any stimuli that induce loss of these cells can induce kidney …

The WNT signaling pathways are major regulators of organ development. Ample research
over the past few decades revealed that these pathways are critically involved in adult tissue …

Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular
network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary …

Abstract Background and Purpose Fibrosis in kidney allografts is a major post‐transplant
complication that contributes to graft failure. Lately, multiple potent inhibitors of fibrosis …

Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular
network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary …

Great efforts have been made toward addressing the demand for donor kidneys. One of the
most promising approaches is to use kidneys from donation after circulatory death donors …

Renal fibrosis is characterized by progressive accumulation of extracellular matrix (ECM)
proteins, resulting in loss of organ function and eventually requiring renal replacement …

Animal models are a valuable tool in preclinical research. However, limited predictivity of
human biological responses in the conventional models has stimulated the search for …

Background Pulmonary hypertension (PH) is a deadly disease characterized by vascular
stiffness and altered cellular metabolism. Current treatments focus on vasodilation and not …

Abstract Liver kinase B1 (LKB1) is a serine/threonine kinase controlling cell homeostasis.
Among post-translational modification, Sumoylation is vital for LKB1 activating adenosine 5' …