Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …

Cytokines constitute a significant portion of the immuno‐and neuromodulatory messengers
that can be released by activated microglia. By virtue of potent effects on resident and …

Pathological aggregation of tau is a hallmark of Alzheimer's disease and related
tauopathies. We have previously shown that the deficiency of the microglial fractalkine …

Autism is a neurodevelopmental disorder characterized by impaired communication and
social interaction and may be accompanied by mental retardation and epilepsy. Its cause …

New hippocampal neurons are continuously generated in the adult brain. Here, we
demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia …

Microglia are the primary immune cells of the central nervous system that help nourish and
support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their …

Aggregates of the hyperphosphorylated microtubule-associated protein tau (MAPT) are an
invariant neuropathological feature of tauopathies. Here, we show that microglial …

Radiation-induced late brain injury consisting of vascular abnormalities, demyelination,
white matter necrosis, and cognitive impairment has been described in patients subjected to …

The idea of the existence of an interaction between the immune system and the central
nervous system (CNS) has prompted extensive research interest into the subject of “ …

The microtubule-associated protein (MAP) tau plays a critical role in the pathogenesis of
tauopathies. Excess tau can be released into the extracellular medium in a physiological or …