Glutamate receptor ion channels: structure, regulation, and function

SF Traynelis, LP Wollmuth, CJ McBain, FS Menniti… - Pharmacological …, 2010 - ASPET
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

The glutamate receptor ion channels

R Dingledine, K Borges, D Bowie, SF Traynelis - Pharmacological reviews, 1999 - ASPET
The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …

Cognitive enhancement: methods, ethics, regulatory challenges

N Bostrom, A Sandberg - Science and engineering ethics, 2009 - Springer
Cognitive enhancement takes many and diverse forms. Various methods of cognitive
enhancement have implications for the near future. At the same time, these technologies …

On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis

RT Bartus - Experimental neurology, 2000 - Elsevier
Life's Journey If life is indeed a journey, then poetry must be the map that reveals all its
topographic possibilities… while science is the compass that keeps us from getting lost.—RT …

Assessment of spatial memory in mice

S Sharma, S Rakoczy, H Brown-Borg - Life sciences, 2010 - Elsevier
Improvements in health care have greatly increased life span in the United States. The focus
is now shifting from physical well-being to improvement in mental well-being or maintenance …

The perils of cognitive enhancement and the urgent imperative to enhance the moral character of humanity

I Persson, J Savulescu - Journal of applied philosophy, 2008 - Wiley Online Library
abstract As history shows, some human beings are capable of acting very immorally. 1
Technological advance and consequent exponential growth in cognitive power means that …

Glutamate and schizophrenia: phencyclidine, N‐methyl‐d‐aspartate receptors, and dopamine–glutamate interactions

DC Javitt - International review of neurobiology, 2007 - Elsevier
Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide.
As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date …

[图书][B] Memory from A to Z: Keywords, concepts, and beyond

Y Dudai - 2004 - books.google.com
This is an innovative and engaging companion to the language of memory research. It
consists of over 130 entries, bound within a coherent conceptual framework. Each entry …

Interactions between tumor cells, neurons, and microglia in the glioma microenvironment

DP Radin, SE Tsirka - International journal of molecular sciences, 2020 - mdpi.com
Despite significant strides made in understanding the pathophysiology of high-grade
gliomas over the past two decades, most patients succumb to these neoplasias within two …

Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression

HK Manji, JA Quiroz, J Sporn, JL Payne, K Denicoff… - Biological …, 2003 - Elsevier
There is growing evidence from neuroimaging and ostmortem studies that severe mood
disorders, which have traditionally been conceptualized as neurochemical disorders, are …