Suppression of antitumor immune responses is one of the main mechanisms by which tumor
cells escape from destruction by the immune system. Myeloid-derived suppressor cells …

Physical exercise has gradually become a focus in cancer treatment due to its pronounced
role in reducing cancer risk, enhancing therapeutic efficacy, and improving prognosis. In …

Exercise is recognized by clinicians in the field of clinical oncology for its potential role in
reducing the risk of certain cancers and in reducing the risk of disease recurrence and …

Adipose tissue is a complex organ with endocrine, metabolic and immune regulatory roles.
Adipose depots have been characterized to release several adipocytokines that work locally …

Environmental and genetic aspects are reflected in the development of prostate cancer. In
this context, there is growing evidence that chronic inflammation is involved in the regulation …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Signal transducers and activators of transcription (STATs) were identified originally as key
components of cytokine signaling pathways. More recently, constitutive activation of STAT …

Purpose: Pathologic examination of prostate glands removed from patients with prostate
cancer commonly reveals infiltrating CD4+ and CD8+ T cells. Little is known about the …

Context: Although androgen deprivation therapy (ADT) for prostate cancer is associated with
bone loss, little is known about when this bone loss occurs. Objective: We postulated that …

The androgen receptor (AR) is a ligand-activated transcription factor that mediates the
biological responses of androgens. However, non-androgenic pathways have also been …