Recent studies have expanded our knowledge, at the molecular level, of how myelin inhibits
axonal regeneration after injury to the mammalian central nervous system. Several inhibitors …

The membrane protein Nogo-A was initially characterized as a CNS-specific inhibitor of
axonal regeneration. Recent studies have uncovered regulatory roles of Nogo proteins and …

Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small
GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such …

Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes
and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and …

Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in
myelin, Nogo and myelin-associated glycoprotein (MAG). The receptor for Nogo (NgR) has …

Nogo-A is a potent neurite growth inhibitor in vitro and plays a role both in the restriction of
axonal regeneration after injury and in structural plasticity in the CNS of higher vertebrates …

Functional recovery after adult CNS damage is limited in part by myelin inhibitors of axonal
regrowth. Three molecules, Nogo-A, MAG, and OMgp, are produced by oligodendrocytes …

A major obstacle for successful axon regeneration in the adult central nervous system (CNS)
arises from inhibitory molecules in CNS myelin, which signal through a common receptor …

After injury, axons of the adult mammalian brain and spinal cord exhibit little regeneration. It
has been suggested that axon growth inhibitors, such as myelin-derived Nogo, prevent CNS …

Abstract Myelin-associated glycoprotein (MAG), an inhibitor of axon regeneration, binds with
high affinity to the Nogo-66 receptor (NgR). Here we report that the p75 neurotrophin …