Potassium channels participate in many biological functions, from ion homeostasis to
generation and modulation of the electrical membrane potential. They are involved in a …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Activation of complex molecular programs in specific cell lineages governs mammalian
heart development, from a primordial linear tube to a four-chamber organ. To characterize …

Background—Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical
challenge. Mechanism-based approaches to AF therapy are sought to increase …

The sinus node is a collection of highly specialised cells constituting the heart's pacemaker.
The molecular underpinnings of its pacemaking abilities are debated. Using high-resolution …

Advances in genomics and next-generation sequencing have provided clinical researchers
with unprecedented opportunities to understand the molecular basis of human genetic …

Atrial fibrillation (AF) is the clinically most prevalent rhythm disorder with large impact on
quality of life and increased risk for hospitalizations and mortality in both men and women. In …

Two-pore domain potassium (K2P) channels stabilize the resting membrane potential of
both excitable and nonexcitable cells and, as such, are important regulators of cell activity …

Background: Antiarrhythmic drugs are widely used to treat patients with atrial fibrillation (AF),
but the mechanisms conveying their variable effectiveness are not known. Recent data …

Atrial fibrillation (AF) is the most frequent arrhythmia and is associated with substantial
morbidity and mortality. Pathophysiological aspects consist in the activation of pro-fibrotic …