The ATP-driven chaperone valosin-containing protein (VCP)/p97 governs critical steps in
ubiquitin-dependent protein quality control and intracellular signalling pathways. It …

Mitochondria play an important role in maintaining cardiac homeostasis by supplying the
major energy required for cardiac excitation–contraction coupling as well as controlling the …

Autophagy is a catabolic pathway used by cells to support metabolism in response to
starvation and to clear damaged proteins and organelles in response to stress. We report …

With the increasing applications in various fields, the release and accumulation of zinc oxide
(ZnO) nanomaterials ultimately lead to unexpected consequences to environment and …

Autophagy is a conserved eukaryotic mechanism that mediates the removal of long-lived
cytoplasmic macromolecules and damaged organelles via a lysosomal degradative …

Cell types rich in mitochondria, including neurons, display a high energy demand and a
need for calcium buffering. The importance of mitochondria for proper neuronal function is …

Autophagy, hallmarked by the formation of double-membrane bound organelles known as
autophagosomes, is a lysosome-dependent pathway for protein degradation. The role of …

Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process
performed by lysosomes in which aggregated and altered proteins as well as dysfunctional …

Autophagy is the mechanism by which cells consume parts of themselves to survive
starvation and stress. This self-cannibalization limits cell death and tissue inflammation …

Macroautophagy (autophagy hereafter) is a catabolic process by which cells degrade
intracellular components in lysosomes. This cellular garbage disposal and intracellular …