Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies

S Ben-Shabat, L Yarmolinsky, D Porat… - Drug delivery and …, 2020 - Springer
Viral infections affect three to five million patients annually. While commonly used antivirals
often show limited efficacy and serious adverse effects, herbal extracts have been in use for …

Pentacyclic triterpene bioavailability: An overview of in vitro and in vivo studies

NA JC Furtado, L Pirson, H Edelberg, L M. Miranda… - Molecules, 2017 - mdpi.com
Pentacyclic triterpenes are naturally found in a great variety of fruits, vegetables and
medicinal plants and are therefore part of the human diet. The beneficial health effects of …

Herbal nanomedicines: Recent advancements, challenges, opportunities and regulatory overview

PK Teja, J Mithiya, AS Kate, K Bairwa, SK Chauthe - Phytomedicine, 2022 - Elsevier
Abstract Background Herbal Nano Medicines (HNMs) are nano-sized medicine containing
herbal drugs as extracts, enriched fractions or biomarker constituents. HNMs have certain …

Self-nanoemulsifying drug delivery system (SNEDDS) with enhanced solubilization of nystatin for treatment of oral candidiasis: Design, optimization, in vitro and in …

AA Kassem, AM Mohsen, RS Ahmed… - Journal of molecular …, 2016 - Elsevier
The aim of the present study is to develop and optimize self-nanoemulsifying drug delivery
systems (SNEDDSs) to improve the per-oral bioavailability of poorly soluble polyene …

Corosolic acid and its structural analogs: A systematic review of their biological activities and underlying mechanism of action

XP Qian, XH Zhang, LN Sun, WF Xing, Y Wang… - Phytomedicine, 2021 - Elsevier
Background The corosolic acid (CA), also known as plant insulin, is a pentacyclic
triterpenoid extracted from plants such as Lagerstroemia speciosa. It has been shown to …

Prodrugs of triterpenoids and their derivatives

M Zhou, RH Zhang, M Wang, GB Xu, SG Liao - European Journal of …, 2017 - Elsevier
Triterpenoids are structurally diverse organic compounds that exist widely as natural
products. Triterpenoids and their derivatives possess a wide range of biological effects …

[HTML][HTML] Development and evaluation of oleanolic acid dosage forms and its derivatives

A Feng, S Yang, Y Sun, L Zhang, F Bo… - BioMed Research …, 2020 - hindawi.com
Oleanolic acid is a pentacyclic triterpenoid compound that exists widely in medicinal herbs
and other plants. Because of the extensive pharmacological activity, oleanolic acid has …

Bioactive based nanocarriers for the treatment of viral infections and SARS-CoV-2

R Goyal, R Bala, RK Sindhu, M Zehravi, R Madaan… - Nanomaterials, 2022 - mdpi.com
Since ancient times, plants have been used for their medicinal properties. They provide us
with many phytomolecules, which serve a synergistic function for human well-being. Along …

Oral Brain-Targeted Microemulsion for Enhanced Piperine Delivery in Alzheimer's Disease Therapy: In Vitro Appraisal, In Vivo Activity, and Nanotoxicity

SM Etman, YSR Elnaggar, DA Abdelmonsif… - AAPS …, 2018 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder that has no cure till now. Piperine
(PIP) is an alkaloid characterized by memory-enhancing properties but challenging oral …

Oleanolic acid and related triterpenoids from olives on vascular function: Molecular mechanisms and therapeutic perspectives

R Rodriguez-Rodriguez - Current medicinal chemistry, 2015 - ingentaconnect.com
Oleanolic acid and related triterpenoids from olives modulate different signaling pathways,
showing a wide range of pharmacological activities against inflammation, cancer or …