EGFR signaling pathway as therapeutic target in human cancers
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …
Paediatric and adult glioblastoma: multiform (epi) genomic culprits emerge
We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
Single-cell RNA sequencing reveals evolution of immune landscape during glioblastoma progression
Glioblastoma (GBM) is an incurable primary malignant brain cancer hallmarked with a
substantial protumorigenic immune component. Knowledge of the GBM immune …
substantial protumorigenic immune component. Knowledge of the GBM immune …
Human glioblastoma arises from subventricular zone cells with low-level driver mutations
Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …
Multiplexed profiling of single extracellular vesicles
Extracellular vesicles (EV) are a family of cell-originating, membrane-enveloped
nanoparticles with diverse biological function, diagnostic potential, and therapeutic …
nanoparticles with diverse biological function, diagnostic potential, and therapeutic …
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
Glioblastomas shed large quantities of small, membrane-bound microvesicles into the
circulation. Although these hold promise as potential biomarkers of therapeutic response …
circulation. Although these hold promise as potential biomarkers of therapeutic response …
Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma
As tumours evolve, the daughter cells of the initiating cell often become molecularly
heterogeneous and develop different functional properties and therapeutic vulnerabilities. In …
heterogeneous and develop different functional properties and therapeutic vulnerabilities. In …
Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma
To understand the relationships between the non-GCIMP glioblastoma (GBM) subgroups,
we performed mathematical modeling to predict the temporal sequence of driver events …
we performed mathematical modeling to predict the temporal sequence of driver events …
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice
Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain
tumor in humans. Here we show that gliomas can originate from differentiated cells in the …
tumor in humans. Here we show that gliomas can originate from differentiated cells in the …
Targeting autophagy to sensitive glioma to temozolomide treatment
Y Yan, Z Xu, S Dai, L Qian, L Sun, Z Gong - Journal of experimental & …, 2016 - Springer
Temozolomide (TMZ), an alkylating agent, is widely used for treating primary and recurrent
high-grade gliomas. However, the efficacy of TMZ is often limited by the development of …
high-grade gliomas. However, the efficacy of TMZ is often limited by the development of …