Chromosomal fragile sites are specific loci that preferentially exhibit gaps and breaks on
metaphase chromosomes following partial inhibition of DNA synthesis. Their discovery has …

Common fragile sites are large chromosomal regions that preferentially exhibit gaps or
breaks after DNA synthesis is partially perturbed. Fragile site instability in cultured cells is …

We show that the time required to transcribe human genes larger than 800 kb spans more
than one complete cell cycle, while their transcription speed equals that of smaller genes …

Perturbed DNA replication in early stages of cancer development induces chromosomal
instability preferentially at fragile sites. However, the molecular basis for this instability is …

Common fragile sites are regions of human chromosomes prone to breakage. Fragile site
FRA16D spans the WWOX/FOR tumor suppressor gene and has been linked to cancer …

Chromosomal common fragile sites (CFSs) are unstable genomic regions that break under
replication stress and are involved in structural variation. They frequently are sites of …

The WW domain‐containing oxidoreductase (WWOX) spans one of the most active common
fragile sites (CFSs) involved in cancer, FRA16D. WWOX encodes a 46‐kDa protein that …

In metazoan cells, only a limited number of mini chromosome maintenance (MCM)
complexes are fired during S phase, while the majority remain dormant. Several methods …

Homologous recombination between dispersed repeated genetic elements is an important
source of genetic variation. In this review, we discuss chromosome rearrangements that are …

Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by mutations in the
FMR1 gene and deficiency of a functional FMRP protein. FMRP is known as a translation …