The neuromuscular junction (NMJ) is a specialized cholinergic synaptic interface between a
motor neuron and a skeletal muscle fiber that translates presynaptic electrical impulses into …

As a promising alternative to autologous nerve grafts, tissue-engineered nerve grafts have
been extensively studied as a way to bridge peripheral nerve defects and guide nerve …

Growth/differentiation factor-15 (GDF-15) is a widely expressed distant member of the TGF-β
superfamily with prominent neurotrophic effects on midbrain dopaminergic neurons. We …

Peripheral neuropathy is a common and major complication of diabetes, the underlying
mechanisms of which are not fully understood. Using a mouse model of type II diabetes, the …

Our previous studies indicated that RhoA knockdown or inhibition could alleviate the
proliferation, migration, and differentiation of Schwann cells. However, the role of RhoA in …

A culture system that can recapitulate myelination in vitro will not only help us better
understand the mechanism of myelination and demyelination, but also find out possible …

Tissue engineered nerve grafts are considered as a promising alternative to autologous
nerve grafts used for peripheral nerve repair. The differences between these two types of …

Low levels of survival of motor neuron (SMN) protein lead to spinal muscular atrophy (SMA).
The major pathological hallmark of SMA is a loss of lower motor neurons from spinal cord …

The established protocols for in vitro studies of peripheral nerve myelination with rat
embryonic dorsal root ganglia (DRG) and postnatal Schwann cell cocultures do not work …

Recent advances in three-dimensional (3D) cell culture models developed on organ-on-a-
chip or microfluidic devices have shown their capability to recapitulate the in vivo …