Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …

Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that
involve G-quartets linked by loop nucleotides. The structural and topological diversity of G …

Background Increasing studies have shown that long noncoding RNAs (lncRNAs) are
pivotal regulators participating in carcinogenic progression and tumor metastasis in …

Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-
quadruplexes. These structures may be very stable under physiological conditions …

Long noncoding RNAs (lncRNAs) play a pivotal role in the regulation of biological
processes through various mechanisms that are not fully understood. Proposed …

Cervical cancer (CC) is the third most common carcinoma and the fourth leading cause of
cancer-associated mortality in women. Here, we report that MDM2-DHX9 interaction …

Triplex DNA structures, formed when a third DNA strand wraps around the major groove of
DNA, are key molecular regulators and genomic threats. However, the regulatory network …

Oncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop
formation are known to impede S phase progression. Nonetheless, cancer cells …

DHX9 is member of the DExD/H-box family of helicases with a “DEIH” sequence at its
eponymous DExH-box motif. Initially purified from human and bovine cells and identified as …

Since the discovery of the DNA double helix, there has been a fascination in understanding
the molecular mechanisms and cellular processes that account for:(i) the transmission of …