Raman spectroscopy: guiding light for the extracellular matrix

MS Bergholt, A Serio, MB Albro - Frontiers in bioengineering and …, 2019 - frontiersin.org
The extracellular matrix (ECM) consists of a complex mesh of proteins, glycoproteins, and
glycosaminoglycans, and is essential for maintaining the integrity and function of biological …

Applications of vibrational spectroscopy for analysis of connective tissues

W Querido, S Kandel, N Pleshko - Molecules, 2021 - mdpi.com
Advances in vibrational spectroscopy have propelled new insights into the molecular
composition and structure of biological tissues. In this review, we discuss common …

Raman spectroscopy reveals new insights into the zonal organization of native and tissue-engineered articular cartilage

MS Bergholt, JP St-Pierre, GS Offeddu… - ACS central …, 2016 - ACS Publications
Tissue architecture is intimately linked with its functions, and loss of tissue organization is
often associated with pathologies. The intricate depth-dependent extracellular matrix (ECM) …

Direct identification and visualisation of real-world contaminating microplastics using Raman spectral mapping with multivariate curve resolution-alternating least …

M Tian, CLM Morais, H Shen, W Pang, L Xu… - Journal of Hazardous …, 2022 - Elsevier
Microplastics (MPs) contamination is ubiquitous in environmental matrices worldwide.
Moreover these pollutants can be ingested by organisms and transported to organs via the …

Raman spectroscopy in biomedicine–non‐invasive in vitro analysis of cells and extracellular matrix components in tissues

E Brauchle, K Schenke‐Layland - Biotechnology journal, 2013 - Wiley Online Library
Raman spectroscopy is an established laser‐based technology for the quality assurance of
pharmaceutical products. Over the past few years, Raman spectroscopy has become a …

Recellularization and integration of dense extracellular matrix by percolation of tissue microparticles

JE Barthold, BM St. Martin, SL Sridhar… - Advanced functional …, 2021 - Wiley Online Library
Cells embedded in the extracellular matrix of tissues play a critical role in maintaining
homeostasis while promoting integration and regeneration following damage or disease …

Raman spectroscopic imaging for quantification of depth-dependent and local heterogeneities in native and engineered cartilage

MB Albro, MS Bergholt, JP St-Pierre… - NPJ Regenerative …, 2018 - nature.com
Articular cartilage possesses a remarkable, mechanically-robust extracellular matrix (ECM)
that is organized and distributed throughout the tissue to resist physiologic strains and …

Highly sensitive impedimetric immunosensor for determination of interleukin 6 as a cancer biomarker by using conjugated polymer containing epoxy side groups …

EB Aydın - Talanta, 2020 - Elsevier
A novel impedimetric immunosensor based on a conjugated polypyrrole polymer containing
epoxy active side groups (PPCE) modified indium tin oxide (ITO) electrode was developed …

Fabrication of electrochemical immunosensor based on acid-substituted poly (pyrrole) polymer modified disposable ITO electrode for sensitive detection of CCR4 …

EB Aydın, M Aydın, MK Sezgintürk - Talanta, 2021 - Elsevier
This study described the first impedimetric immunosensor reported for the determination of
CCR4, a new prostate cancer biomarker. This impedimetric immunosensor was constructed …

FTIR‐I compositional mapping of the cartilage‐to‐bone interface as a function of tissue region and age

NT Khanarian, MK Boushell, JP Spalazzi… - Journal of Bone and …, 2014 - academic.oup.com
Soft tissue‐to‐bone transitions, such as the osteochondral interface, are complex junctions
that connect multiple tissue types and are critical for musculoskeletal function. The …