The medicinal chemistry of ferrocene and its derivatives
Ferrocene derivatives have attracted significant interest as anticancer, antibacterial,
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …
antifungal and antiparasitic drug candidates. Discovered in the 1990s, the two most …
Ferrocene-containing hybrids as potential anticancer agents: Current developments, mechanisms of action and structure-activity relationships
Cancer is one of the most fatal threatens to human health throughout the world. The major
challenges in the control and eradication of cancers are the continuous emergency of drug …
challenges in the control and eradication of cancers are the continuous emergency of drug …
Introduction to FOXO biology
W Link - FOXO Transcription Factors: Methods and Protocols, 2019 - Springer
Forkhead box O (FOXO) proteins are a family of transcription factors with four members in
mammals, namely FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO factors, originally identified …
mammals, namely FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO factors, originally identified …
[HTML][HTML] Oncogenic regulation of tumor metabolic reprogramming
Abstract Development of malignancy is accompanied by a complete metabolic
reprogramming closely related to the acquisition of most of cancer hallmarks. In fact, key …
reprogramming closely related to the acquisition of most of cancer hallmarks. In fact, key …
Recent advances in the chemistry of iron-based chemotherapeutic agents
The discovery of cisplatin followed by its success in anticancer therapy laid the foundation of
metal-based drug design and development. Further research led to discovery of other …
metal-based drug design and development. Further research led to discovery of other …
FOXO transcription factors at the interface of metabolism and cancer
W Link, PJ Fernandez‐Marcos - International journal of cancer, 2017 - Wiley Online Library
Diabetes refers to a group of metabolic diseases characterized by impaired insulin
signalling and high blood glucose. A growing body of epidemiological evidence links …
signalling and high blood glucose. A growing body of epidemiological evidence links …
ROS‐Responsive N‐Alkylaminoferrocenes for Cancer‐Cell‐Specific Targeting of Mitochondria
V Reshetnikov, S Daum, C Janko… - Angewandte …, 2018 - Wiley Online Library
Mitochondrial membrane potential is more negative in cancer cells than in normal cells,
allowing cancer targeting by delocalized lipophilic cations (DLCs). However, as the …
allowing cancer targeting by delocalized lipophilic cations (DLCs). However, as the …
Applications of five-membered ring products of cyclometalation reactions as anticancer agents
I Omae - Coordination Chemistry Reviews, 2014 - Elsevier
The use of metal compounds as anticancer agents is one of the applications of the five-
membered ring products of cyclometalation reactions, including those with Pt, Pd, Rh, Ir, Ru …
membered ring products of cyclometalation reactions, including those with Pt, Pd, Rh, Ir, Ru …
Catalytically generated ferrocene-containing guanidines as efficient precursors for new redox-active heterometallic platinum (II) complexes with anticancer activity
The potential of structurally new ferrocene-functionalized guanidines as redox-active
precursors for the synthesis of heterometallic platinum (II)–guanidine complexes with …
precursors for the synthesis of heterometallic platinum (II)–guanidine complexes with …
Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition
M Tarrado-Castellarnau, R Cortes, M Zanuy… - Pharmacological …, 2015 - Elsevier
Selenium supplement has been shown in clinical trials to reduce the risk of different cancers
including lung carcinoma. Previous studies reported that the antiproliferative and pro …
including lung carcinoma. Previous studies reported that the antiproliferative and pro …