A recurrent theme in embryonic development and tissue regeneration is that cells
communicate with each other using just a handful of conserved families of signaling …

Testing the many hypotheses from genomics and systems biology experiments demands
accurate and cost-effective gene and genome synthesis. Here we describe a microchip …

Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors
to the primary cilium. Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have …

The Hippo tumor suppressor pathway plays an important role in tissue homeostasis that
ensures development of functional organs at proper size. The YAP transcription coactivator …

In vertebrates, Hedgehog (Hh) signaling initiated in primary cilia activates the membrane
protein Smoothened (Smo) and leads to activation of Gli proteins, the transcriptional …

Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal
development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a …

Wingless (Wg), a founding member of the Wingless/Int-1 (Wnt) family of secreted proteins,
acts as a short-range inducer and as a long-range organizer during Drosophila …

A fundamental goal of genetics and functional genomics is to identify and mutate every gene
in model organisms such as Drosophila melanogaster. The Berkeley Drosophila Genome …

Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal
development and cancer. We describe a program of multisite phosphorylation that regulates …

The signaling protein Hedgehog (Hh) controls cell fate and polarizes tissues in both flies
and vertebrates. In flies, Hh exerts its effects by opposing the function of a novel …