Abstract Fibroblast growth factor 21 (FGF21) is a stress-inducible hormone that has
important roles in regulating energy balance and glucose and lipid homeostasis through a …

Mammalian adipose tissue can be divided into two major types, namely, white adipose
tissue (WAT) and brown adipose tissue (BAT). According to classical view, the main function …

Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

In recent decades, obesity has extensively emerged to the level of pandemics. It's
significantly associated with serious co-morbidities that could decrease life quality and even …

Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-
associated metabolic complications. However, the molecular links between lipid-overloaded …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …

Obesity is a complex condition that is characterized by excessive fat accumulation, which
can lead to the development of metabolic disorders, such as type 2 diabetes mellitus …

The prevalence of overweight and obesity in developed and developing countries has
greatly increased the risk of insulin resistance and type 2 diabetes mellitus. It is evident from …

White adipocytes store excess energy in the form of triglycerides, whereas brown and beige
adipocytes dissipate energy in the form of heat. This thermogenic function relies on the …