The use of chemicals around the globe in different industries has increased tremendously,
affecting the health of people. The modern world intends to replace these noxious chemicals …

Proteases have an important role in many signalling pathways, and represent potential drug
targets for diseases ranging from cardiovascular disorders to cancer, as well as for …

R-Aminophosphonic acids are broadly defined as analogues of amino acids in which the
carboxylic group is replaced by a phosphonic acid or related group (usually phosphonous or …

Formation of malaria pigment or haemozoin is the major route of haem detoxification in the
malaria parasite Plasmodium falciparum as well as several other species of …

During the erythrocytic stage of its life cycle, the human malaria parasite Plasmodium
falciparum catabolizes large quantities of host-cell hemoglobin in an acidic organelle, the …

Plasmodium falciparum parasites are responsible for the major global disease malaria,
which results in> 2 million deaths each year. With the rise of drug-resistant malarial …

Malaria causes worldwide morbidity and mortality, and while chemotherapy remains an
excellent means of malaria control, drug-resistant parasites necessitate the discovery of new …

Aminopeptidases are enzymes that selectively hydrolyze an amino acid residue from the N-
terminus of proteins and peptides. They are important for the proper functioning of …

The neutral aminopeptidases M1 alanyl aminopeptidase (PfM1AAP) and M17 leucine
aminopeptidase (PfM17LAP) of the human malaria parasite Plasmodium falciparum are …

CHR-2797 is a novel metalloenzyme inhibitor that is converted into a pharmacologically
active acid product (CHR-79888) inside cells. CHR-79888 is a potent inhibitor of a number …