Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily
localized in the excitatory synapses. Sophisticated imaging techniques revealed that …

Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether
polarity loss might causally contribute to cancer has remained unclear. In Drosophila …

Structure–function relationships in proteins are predicated on the spatial proximity of
noncovalently interacting groups of atoms. Thus, structural elements located away from a …

Synaptic junctions are highly specialized structures designed to promote the rapid and
efficient transmission of signals from the presynaptic terminal to the postsynaptic membrane …

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are of fundamental
importance in the brain. They are responsible for the majority of fast excitatory synaptic …

The present study examined the levels of NMDA receptor NR2 subunit tyrosine
phosphorylation in a rat model of inflammation and correlated it with the development of …

We have identified truncating mutations in the human DLG3 (neuroendocrine dlg) gene in 4
of 329 families with moderate to severe X-linked mental retardation. DLG3 encodes synapse …

The synthesis of brain phosphatidylcholine may utilize three circulating precursors: choline;
a pyrimidine (eg, uridine, converted via UTP to brain CTP); and a PUFA (eg …

Voltage-gated sodium channels (VGSC) are multi-molecular protein complexes expressed
in both excitable and non-excitable cells. They are primarily formed by a pore-forming multi …

▪ Abstract Myosin motor proteins use the energy derived from ATP hydrolysis to move cargo
along actin tracks. Myosin VI, unlike almost all other myosins, moves toward the minus end …