Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling
Lung cancer (LC) continues to pose a significant global medical burden, necessitating a
comprehensive understanding of its molecular foundations to establish effective treatment …
comprehensive understanding of its molecular foundations to establish effective treatment …
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway
N Furth, Y Aylon - Cell Death & Differentiation, 2017 - nature.com
Proper cellular functionality and homeostasis are maintained by the convergent integration
of various signaling cascades, which enable cells to respond to internal and external …
of various signaling cascades, which enable cells to respond to internal and external …
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 …
C Zhou, C Yi, Y Yi, W Qin, Y Yan, X Dong, X Zhang… - Molecular cancer, 2020 - Springer
Background Pancreatic cancer is one of the most lethal malignancies and has an extremely
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …
Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression
X Zang, J Gu, J Zhang, H Shi, S Hou, X Xu… - Cell death & …, 2020 - nature.com
Abstract Long non-coding RNAs (LncRNAs) have been suggested as important regulators of
cancer development and progression in non-small cell lung cancer (NSCLC). Nevertheless …
cancer development and progression in non-small cell lung cancer (NSCLC). Nevertheless …
The lncRNA PVT1 regulates nasopharyngeal carcinoma cell proliferation via activating the KAT2A acetyltransferase and stabilizing HIF-1α
Y Wang, W Chen, J Lian, H Zhang, B Yu… - Cell Death & …, 2020 - nature.com
Long noncoding RNAs (lncRNAs) play important roles in regulating the development and
progression of many cancers. However, the clinical significance of specific lncRNAs in the …
progression of many cancers. However, the clinical significance of specific lncRNAs in the …
m6A methyltransferase METTL3-induced lncRNA SNHG17 promotes lung adenocarcinoma gefitinib resistance by epigenetically repressing LATS2 expression
H Zhang, SQ Wang, L Wang, H Lin, JB Zhu… - Cell Death & …, 2022 - nature.com
Gefitinib has been widely applied for the treatment of lung adenocarcinoma (LUAD).
However, the long-term application of gefitinib usually leads to acquired drug resistance in …
However, the long-term application of gefitinib usually leads to acquired drug resistance in …
Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis
K Jin, S Wang, Y Zhang, M Xia, Y Mo, X Li, G Li… - Cellular and molecular …, 2019 - Springer
Numerous studies have shown that non-coding RNAs play crucial roles in the development
and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly …
and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly …
[HTML][HTML] Long non-coding RNAs in anti-cancer drug resistance
Q Chen, C Wei, Z Wang, M Sun - Oncotarget, 2017 - ncbi.nlm.nih.gov
Chemotherapy is one of the basic treatments for cancers; however, drug resistance is mainly
responsible for the failure of clinical treatment. The mechanism of drug resistance is …
responsible for the failure of clinical treatment. The mechanism of drug resistance is …
LncRNA PVT1 regulates triple-negative breast cancer through KLF5/beta-catenin signaling
J Tang, Y Li, Y Sang, B Yu, D Lv, W Zhang, H Feng - Oncogene, 2018 - nature.com
Recent molecularly targeted approach gains advance in breast cancer treatment. However,
the estimated 5-year survival rate has not met the desired expectation for improvement …
the estimated 5-year survival rate has not met the desired expectation for improvement …
Dysregulated long noncoding RNAs (lncRNAs) in hepatocellular carcinoma: implications for tumorigenesis, disease progression, and liver cancer stem cells
X Huo, S Han, G Wu, O Latchoumanin, G Zhou… - Molecular cancer, 2017 - Springer
Hepatocellular carcinoma (HCC) is one of the most common malignant tumours with a poor
prognosis worldwide. While early stage tumours can be treated with curative approaches …
prognosis worldwide. While early stage tumours can be treated with curative approaches …