Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Most cancers arise in individuals over the age of 60. As the world population is living longer
and reaching older ages, cancer is becoming a substantial public health problem. It is …

The novel SARS-CoV-2 coronavirus, which is responsible for COVID-19 disease, was first
reported in Wuhan, China, in December of 2019. The virus rapidly spread, and the World …

Integrins are heterodimeric transmembrane cell adhesion molecules made up of alpha (α)
and beta (β) subunits arranged in numerous dimeric pairings. These complexes have …

The mechanics of the cellular microenvironment continuously modulates cell functions such
as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal …

Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Aging promotes lung function decline and susceptibility to chronic lung diseases, which are
the third leading cause of death worldwide. Here, we use single cell transcriptomics and …

The structure of connective tissues including cartilage, tendons, and ligaments as well as
many organs, like the skin, heart, liver, kidney, lungs, blood vessels, and bones, depend on …

Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …