Cyclophosphamide reduces gene transcriptional activity and embryo in vitro development by inhibiting NF-κB expression through decreasing AcH4K12

ZB Luo, LH Yang, SZ Han, SY Chang, H Liu… - Chemico-Biological …, 2024 - Elsevier
Cyclophosphamide (CTX), a widely used chemotherapeutic agent for cancer treatment, has
been associated with long-term toxicity and detrimental effects on oocytes and ovaries …

RNA interference-mediated silencing of DNA methyltransferase 1 attenuates neuropathic pain by accelerating microglia M2 polarization

Y Tan, Z Wang, T Liu, P Gao, S Xu, L Tan - BMC neurology, 2022 - Springer
Abstract Background DNA methyltransferase 1 (DNMT1) exerts imperative functions in
neuropathic pain (NP). This study explored the action of RNA interference-mediated DNMT1 …

[HTML][HTML] Pan-cancer analysis of 60S Ribosomal Protein L7-Like 1 (RPL7L1) and validation in liver hepatocellular carcinoma

KJ He, G Gong, E Liang, Y Lv, S Lin, J Xu - Translational Oncology, 2024 - Elsevier
Background and aims There is an association between cancer and increased ribosome
biogenesis. At present, the RPL7L1 (60S Ribosomal Protein L7-Like 1) were less reported …

[HTML][HTML] 动物早期胚胎发育中表观重编程的机制

余彤, 任斌斌, 郑睿智, 朱文治, 苏建民 - 畜牧兽医学报, 2023 - html.rhhz.net
哺乳动物早期胚胎发育过程中, 受精卵经历了一系列表观遗传重编程事件,
去除了雌雄原核的表观遗传记忆, 从而建立了胚胎的全能性. 然而, 这些重编程事件的进行必须 …