Bioactive peptide discovery from edible insects for potential applications in human health and agriculture

Y Quah, SR Tong, J Bojarska, K Giller, SA Tan… - Molecules, 2023 - mdpi.com
In the past decade, there has been fast-growing interest among researchers to discover
bioactive peptides from edible insects and to evaluate their potential applications in the …

Exploring the potential of black soldier Fly larval proteins as bioactive peptide sources through in silico gastrointestinal proteolysis: a cheminformatic investigation

FC Wong, YH Lee, JH Ong, FA Manan, MZ Sabri… - Catalysts, 2023 - mdpi.com
Despite their potential as a protein source for human consumption, the health benefits of
black soldier fly larvae (BSFL) proteins following human gastrointestinal (GI) digestion are …

Virtual Screening of Peptide Libraries: The Search for Peptide-Based Therapeutics Using Computational Tools

M Vincenzi, FA Mercurio, M Leone - International Journal of Molecular …, 2024 - mdpi.com
Over the last few decades, we have witnessed growing interest from both academic and
industrial laboratories in peptides as possible therapeutics. Bioactive peptides have a high …

Seafood paramyosins as sources of anti-angiotensin-converting-enzyme and anti-dipeptidyl-peptidase peptides after gastrointestinal digestion: A cheminformatic …

TT Chai, CCC Wong, MZ Sabri, FC Wong - Molecules, 2022 - mdpi.com
Paramyosins, muscle proteins occurring exclusively in invertebrates, are abundant in
seafoods. The potential of seafood paramyosins (SP) as sources of anti-angiotensin …

PyPLIF HIPPOS and receptor ensemble docking increase the prediction accuracy of the structure-based virtual screening protocol targeting acetylcholinesterase

EP Istyastono, FDO Riswanto, N Yuniarti, VD Prasasty… - Molecules, 2022 - mdpi.com
In this article, the upgrading process of the structure-based virtual screening (SBVS) protocol
targeting acetylcholinesterase (AChE) previously published in 2017 is presented. The …

[HTML][HTML] A new ChEMBL dataset for the similarity-based target fishing engine FastTargetPred: Annotation of an exhaustive list of linear tetrapeptides

S Tanwar, P Auberger, G Gillet, M DiPaola, K Tsaioun… - Data in Brief, 2022 - Elsevier
Drug discovery often requires the identification of off-targets as the binding of a compound to
targets other than the intended target (s) can be beneficial in some cases or detrimental in …

[HTML][HTML] Dock-able linear and homodetic di, tri, tetra and pentapeptide library from canonical amino acids: SARS-CoV-2 Mpro as a case study

S Ahmad, MU Mirza, JF Trant - Journal of Pharmaceutical Analysis, 2023 - Elsevier
Peptide-based therapeutics are increasingly pushing to the forefront of biomedicine with
their promise of high specificity and low toxicity. Although noncanonical residues can always …

Identification of Putative Cell‐entry‐inhibitory Peptides against SARS‐CoV‐2 from Edible Insects: An in silico Study

FC Wong, JH Ong, TT Chai - EFood, 2020 - Wiley Online Library
Coronavirus Disease 2019 (COVID‐19), an infectious disease caused by SARS‐CoV‐2, has
become the most contagious pandemic in the world. The binding of SARS‐CoV‐2 spike …

Computer-aided discovery of pentapeptide AEYTR as a potent acetylcholinesterase inhibitor

EP Istyastono, VD Prasasty - Indonesian Journal of Chemistry, 2021 - journal.ugm.ac.id
One of the key targets in the drug development for potential Alzheimer's disease (AD)
therapeutics is the search for acetylcholinesterase enzyme (AChE) inhibitors. Very recently …

PyPLIF HIPPOS-aided construction and retrospective validation of structure-based virtual screening protocol targeting VEGFR2

AB Perdamaian, T Marsifah, RI Jenie… - Indonesian Journal of …, 2024 - journal.ugm.ac.id
Recently, the discovery of small molecules as inhibitors for vascular endothelial growth
factor receptor 2 (VEGFR2) is of timely interest, especially in the area of ocular neovascular …