The centrosome was discovered in the late 19th century when mitosis was first described.
Long recognized as a key organelle of the spindle pole, its core component, the centriole …

Cell proliferation depends on the duplication of chromosomes followed by the segregation of
duplicates (sister chromatids) to opposite poles of the cell prior to cell division (cytokinesis) …

Typical members of the Ras superfamily of small monomeric GTP-binding proteins function
as regulators of diverse processes by cycling between biologically active GTP-and inactive …

A conserved signalling cascade—termed the mitotic-exit network in budding yeast and the
septation-initiation network in fission yeast—controls key events during exit from mitosis and …

Bfa1p and Bub2p are spindle checkpoint proteins that likely have GTPase activation activity
and are associated with the budding yeast spindle pole body (SPB). Here, we show that …

Centrosomes—as well as the related spindle pole bodies (SPBs) of yeast—have been
extensively studied from the perspective of their microtubule-organizing roles. Moreover, the …

Cytokinesis is the final event of the cell division cycle, and its completion results in
irreversible partition of a mother cell into two daughter cells. Cytokinesis was one of the first …

During mitosis, a ras-related GTPase (Tem1) binds GTP and activates a signal transduction
pathway to allow mitotic exit. During most of the cell cycle, Tem1 function is antagonized by …

Centrosomes, spindle pole bodies, and related structures in other organisms are a
morphologically diverse group of organelles that share a common ability to nucleate and …

▪ Abstract The mitotic spindle segregates chromosomes to opposite ends of the cell in
preparation for cell division. Chromosome attachment to the spindle is monitored by the …