Tumor-associated macrophages (TAMs) as immune cells within the tumor microenvironment
have gained much interests as basic science regarding their roles in tumor progression …

Approximately one-half of advanced (unresectable or metastatic) melanomas harbor a
mutation in the BRAF gene, with V600E being the most common mutation. Targeted therapy …

Background Immunohistochemistry (IHC) is a well-established, widely accepted method in
both clinical and experimental parts of medical science. It allows receiving valuable …

Once focused mainly on the characterization of neoplasms, immunohistochemistry (IHC)
today is used in the investigation of a broad range of disease processes with applications in …

Abstract Evaluation of tissues is a common and important aspect of translational research
studies. Labeling techniques such as immunohistochemistry can stain cells/tissues to …

Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the
most authoritative single source of information in the field of toxicologic pathology, has been …

The advent of whole-slide imaging in digital pathology has brought about the advancement
of computer-aided examination of tissue via digital image analysis. Digitized slides can now …

V-Raf murine sarcoma viral oncogene homolog B (BRAF) kinase, which was encoded by
BRAF gene, plays critical roles in cell signaling, growth, and survival. Mutations in BRAF …

Digital pathology, the practice of pathology using digitized images of pathologic specimens,
has been transformed in recent years by the development of whole-slide imaging systems …

This article describes commonly used experimental and clinical biomarkers of neuronal
injury and neurodegeneration for the evaluation of neuropathology and monitoring of …