Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial
when it concerns fat mass, but loss of fat free mass–especially muscle might be detrimental …

Despite the large volume and extensive range of obesity research, there is substantial
disagreement on the causes and effective preventative strategies. We suggest the field will …

The ability to respond to variations in nutritional status depends on regulatory systems that
monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient …

Summary Fibroblast growth factor 21 (FGF21), an endocrine signal robustly increased by
protein restriction independently of an animal's energy status, exerts profound effects on …

Glucagon analogs show promise as components of next-generation, multi-target, anti-
obesity therapeutics. The biology of chronic glucagon treatment, in particular, its ability to …

Several dietary factors (including adherence to the Mediterranean diet or higher nut intake)
seem to positively affect circulating antiaging Klotho protein levels; yet, a description of …

Glucagon receptor (GCGR)-targeted multi-agonists are being developed for the treatment of
obesity and metabolic disease. GCGR activity is utilised for its favourable weight loss and …

Low protein diets are associated with increased lifespan and improved cardiometabolic
health primarily in rodents, and likely improve human health. There is strong evidence that …

Feeding behavior is guided by multiple competing physiological needs, as animals must
sense their internal nutritional state and then identify and consume foods that meet …

Background Diets rich in fats and/or carbohydrates are used to study obesity and related
metabolic complications. We studied the effects of a high fat high fructose diet (HFFD) on …