Abstract Process Systems Engineering (PSE) is the scientific discipline of integrating scales
and components describing the behavior of a physicochemical system, via mathematical …

Successful biologics must satisfy multiple properties including activity and particular
physicochemical features that are globally defined as developability. These multiple …

Highlights•Mathematical models as tools to establish quantitative links between bioprocess
CPPs and KPIs.•Review of the advantages and limitations of mechanistic and statistical …

The rise of personalised and highly complex drug product profiles necessitates significant
advancements in pharmaceutical manufacturing and distribution. Efforts to develop more …

Digital twins (DTs) represent a vividly emerging technology in the manufacturing industry
strongly motivated by the goals of industry 4.0. It strives for smart factories with completely …

Modern technologies and recently developed digital solutions make their way into all
aspects of lives of individuals and businesses, and manufacturing industry is no exception …

While machine learning (ML) has made significant contributions to the biopharmaceutical
field, its applications are still in the early stages in terms of providing direct support for quality …

Monoclonal antibodies are leading the growing biopharmaceutical markets. To sustain the
increasing demand, manufacturing processes should be optimized to increase efficiency …

Proteins, which have inherent biorecognition properties, have long been used as
therapeutic agents for the treatment of a wide variety of clinical indications. Protein …

Abstract Industrial Internet of Things (IIoT) is a system of interconnected devices that, via the
use of various technologies, such as soft sensors, cloud computing, data analytics, machine …