Cyclosporine, the prototype calcineurin inhibitor, transformed immunosuppressant regimens
and practices post-organ transplantation. Therapeutic uses of cyclosporine branched out to …

Heart transplantation (HTx) is the treatment of choice for patients with refractory end-stage
heart diseases. Although the procedure is considered effective in extending and improving …

The endothelium-derived hyperpolarizing factor (EDHF) serves as a back-up mechanism
that compensates for reduced nitric oxide (NO)/prostanoids bioavailability. Here we …

Methotrexate (MTX) is widely used in treatment of cancers and autoimmune diseases.
However, nephrotoxicity is one of its most important side effects. The peroxisome proliferator …

Adenosine A2B-receptors mediate the adenosine-evoked renal vasodilations in male rats.
Here, we tested whether this finding could be replicated in female renal vasculature and …

BACKGROUND: Ischemia-reperfusion injury (IRI) can cause insufficient microcirculation of
the transplanted organ and results in a diminished and inferior graft survival rate …

Kidney transplantation is considered the best treatment for patients with end stage renal
disease. Ischemia-reperfusion injury (IRI) is an evitable event after deceased donor …

Kidney transplantation is considered the best treatment for patients with end stage renal
disease. Ischemia-reperfusion injury (IRI) is an evitable event after deceased donor …

Cardiac and Reno vascular complications remain the major cause of morbidity and mortality
associated with type 2 diabetes mellitus (T2DM). A growing body of evidence suggest that …

Nuclear hormone receptors are master regulators of diverse cellular functions implicated in
tumor pathogenesis and as oncogenic drivers of many human cancers. To better understand …