Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …

Depression is a complex disorder that takes an enormous toll on individual health. As
affected individuals display a wide variation in their clinical symptoms, the precise neural …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

The ventral striatum (nucleus accumbens) and its role in mood, reward, and motivation has
been the focus of significant research. Despite this interest, little work has addressed cell …

Abstract β-catenin is a multi-functional protein that has an important role in the mature
central nervous system; its dysfunction has been implicated in several neuropsychiatric …

Psychiatric disorders are complex multifactorial disorders involving chronic alterations in
neural circuit structure and function. While genetic factors play a role in the etiology of …

While the essential contribution of the hippocampus to spatial memory is well established,
object recognition memory has been traditionally attributed to the perirhinal cortex (PRh) …

ΔFosB is a member of the Fos family of transcription factors. While other family members are
induced rapidly but transiently in response to a host of acute stimuli, ΔFosB is unique in that …

Viable new treatments for depression and anxiety have been slow to emerge, likely owing to
the complex and incompletely understood etiology of these disorders. A budding area of …

Animal studies over the past two decades have led to extensive advances in our
understanding of pathogenesis of depressive and mood disorders. Among these, rodent …