Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

The circadian clock system consists of a central clock located in the suprachiasmatic
nucleus in the hypothalamus and peripheral clocks in peripheral tissues. Peripheral clocks …

Hepatocellular carcinoma (HCC) remains a global health challenge whose incidence is
growing worldwide. Previous evidence strongly supported the notion that the circadian clock …

The occurrence and sequelae of disorders that lead to hypoxic spells such as asthma,
chronic obstructive pulmonary disease, and obstructive sleep apnea (OSA) exhibit daily …

Obstructive sleep apnea (OSA) is a chronic condition characterized by recurrent pauses in
breathing caused by the collapse of the upper airways, which results in intermittent hypoxia …

Disruption of circadian rhythms, which are regulated by the circadian clock machinery, plays
an important role in different long‐term diseases including hepatocellular carcinoma (HCC) …

Current studies have proven that the decreased expression of the core circadian clock gene
Period 1 (PER1) is closely related to the occurrence and progression of multiple malignant …

Hypoxia‐inducible factor 1 (HIF‐1) is a transcription factor functioning in cellular adaptive
responses to hypoxia. Recent studies have suggested that HIF‐1 activity is upregulated by …

Obstructive sleep apnea is the most common sleep‐related breathing disorder worldwide
and remains underdiagnosed. Its multiple associated comorbidities contribute to a …

Humans have internal circadian clocks that ensure that important physiological functions
occur at specific times of the day. These molecular clocks are regulated at the genomic level …