In their natural environment, cells are regularly exposed to various stress conditions that
may lead to protein misfolding, but also in the absence of stress, misfolded proteins occur as …

Homologous recombination between repetitive sequences can lead to gross chromosomal
rearrangements (GCRs). At fission yeast centromeres, Rad51-dependent conservative …

Molecular chaperones, particularly the 70-kDa heat shock proteins (Hsp70s), are key
orchestrators of the cellular stress response. To perform their critical functions, Hsp70s …

In eukaryotes many players in the DNA-damage response (DDR) catalyze protein
sumoylation or ubiquitylation. Emphasis has been placed on how these modifications …

As a result of exposure to stress conditions, mutations, or defects during synthesis, cellular
proteins are prone to misfold. To cope with such partially denatured proteins, cells mount a …

Rho GTPases are conserved molecules that control cytoskeletal dynamics. These functions
are expedited by Rho GEFs that stimulate the release of GDP to enable GTP binding …

Critical cellular functions of Hsp70s require the presence of specific co-chaperones, which
include nucleotide exchange factors containing the BCL2-associated athanogene (BAG) …

Las GTPasas de la familia Rho (Rho1p, Cdc42p, etc.) controlan funciones biológicas tan
importantes como la morfogénesis y la progresión del ciclo celular. Sin embargo, apenas se …

[ES] Las GTPasas de la familia Rho (Rho1p, Cdc42p, etc.) controlan funciones biológicas
tan importantes como la morfogénesis y la progresión del ciclo celular. Sin embargo …

Chromatin is the combination of DNA and proteins that are located in the nucleus of the
eukaryotic cell. Chromatin plays an essential role in genomic regulation, mitosis, meiosis …