Abstract I. Introduction 00 II. Reactive Oxygen and Nitrogen Species 00 III. Biological
Markers of Oxidative/Nitrosative Stress 00 IV. Oxidative/Nitrosative Stress and Protein …

Protein 3-nitrotyrosine is a posttranslational modification found in many pathological
conditions from acute to chronic diseases. Could 3-nitrotyrosine formation participate on the …

Inevitable byproducts of aerobic metabolism are free radicals and other highly reactive
oxidants and nitrosants that are continuously formed within cells. Most cells generally …

There is growing evidence that cardiovascular disease is associated with progressive
changes in the production of free radicals and radical-derived reactive species. These …

The primary function of myoglobin has normally been considered as oxygen storage in
muscles. Other functions of myoglobin seem, however, now to have been identified, since …

Tyrosine hydroxylase (TH) is modified by nitration after exposure of mice to 1-methyl-4-
phenyl-1, 2, 3, 6-tetrahydrophenylpyridine. The temporal association of tyrosine nitration …

Peroxynitrite, a strong oxidant formed intravascularly in vivo, can diffuse onto erythrocytes
and be largely consumed via a fast reaction (2× 10 4 m–1 s–1) with oxyhemoglobin. The …

Reactive‐nitrogen species (RNS) such as peroxynitrite (ONOO−), that is, the reaction
product of nitric oxide (• NO) and superoxide (O2−•), nitryl chloride (NO2Cl) and• NO2 react …

Members of the hemoglobin superfamily efficiently catalyze nitric‐oxide dioxygenation, and
when paired with native electron donors, function as NO dioxygenases (NODs). Indeed, the …

Hemoproteins, in particular, myoglobin and hemoglobin, are among the major targets of
peroxynitrite in vivo. The oxygenated forms of these proteins are oxidized by peroxynitrite to …