Airway neutrophilia is a common feature of many chronic inflammatory lung diseases and is
associated with disease progression, often regardless of the initiating cause. Neutrophils …

The pathology and impact of chronic obstructive pulmonary disease (COPD) results from an
abnormal inflammatory process resulting in tissue damage with ineffective repair in …

Understanding Covid‐19 pathophysiology is crucial for a better understanding of the
disease and development of more effective treatments. Alpha‐1‐antitrypsin (A1AT) is a …

Neutrophils are the predominant immune cells in human blood possessing heterogeneity,
plasticity and functional diversity. The activation and recruitment of neutrophils into inflamed …

Alpha-1 antitrypsin deficiency is linked with an increased risk of suffering from lung
emphysema. This discovery from the 1960s led to the development of the protease …

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by
accumulation of extracellular matrix (ECM) and impaired gas exchange. The pathobiological …

Although exposure to particulate matter with a diameter of< 2.5 μm (PM 2.5) is associated
with chronic obstructive pulmonary disease (COPD), the major components of PM 2.5 in …

Background Panniculitis represents a rare and potentially lethal manifestation of alpha-1
antitrypsin deficiency (AATD). Evidence regarding management is limited to case reports …

Human neutrophil elastase (HNE) is an important N-glycosylated serine protease in the
innate immune system, but the structure and immune-modulating functions of HNE N …

Different mutations in the SERPINA1 gene result in alpha-1 antitrypsin (AAT) deficiency and
in an increased risk for the development of liver diseases. More than 90% of severe …