Diagnostic, therapeutic, and prognostic implications of the 2021 World Health Organization classification of tumors of the central nervous system
S Gritsch, TT Batchelor, LN Gonzalez Castro - Cancer, 2022 - Wiley Online Library
The 2016 revised fourth edition of the World Health Organization (WHO) classification of
central nervous system (CNS) tumors incorporated molecular features with histologic …
central nervous system (CNS) tumors incorporated molecular features with histologic …
DNA methylation profiling: an emerging paradigm for cancer diagnosis
A Papanicolau-Sengos, K Aldape - Annual Review of Pathology …, 2022 - annualreviews.org
Histomorphology has been a mainstay of cancer diagnosis in anatomic pathology for many
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
years. DNA methylation profiling is an additional emerging tool that will serve as an adjunct …
cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading
Abstract cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to
CNS Tumor Taxonomy) was established to evaluate and make practical recommendations …
CNS Tumor Taxonomy) was established to evaluate and make practical recommendations …
[HTML][HTML] Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience
Recently, we described a machine learning approach for classification of central nervous
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …
system tumors based on the analysis of genome-wide DNA methylation patterns [6]. Here …
[HTML][HTML] Glioma subclassifications and their clinical significance
R Chen, M Smith-Cohn, AL Cohen, H Colman - Neurotherapeutics, 2017 - Elsevier
The impact of targeted therapies in glioma has been modest. All the therapies that have
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …
cIMPACT‐NOW update 7: advancing the molecular classification of ependymal tumors
DW Ellison, KD Aldape, D Capper, M Fouladi… - Brain …, 2020 - Wiley Online Library
Advances in our understanding of the biological basis and molecular characteristics of
ependymal tumors since the latest iteration of the World Health Organization (WHO) …
ependymal tumors since the latest iteration of the World Health Organization (WHO) …
Childhood cerebellar tumours mirror conserved fetal transcriptional programs
MC Vladoiu, I El-Hamamy, LK Donovan, H Farooq… - Nature, 2019 - nature.com
Study of the origin and development of cerebellar tumours has been hampered by the
complexity and heterogeneity of cerebellar cells that change over the course of …
complexity and heterogeneity of cerebellar cells that change over the course of …
[HTML][HTML] Molecular classification of ependymal tumors across all CNS compartments, histopathological grades, and age groups
Ependymal tumors across age groups are currently classified and graded solely by
histopathology. It is, however, commonly accepted that this classification scheme has limited …
histopathology. It is, however, commonly accepted that this classification scheme has limited …
Pediatric brain tumors
YT Udaka, RJ Packer - Neurologic clinics, 2018 - neurologic.theclinics.com
Pediatric central nervous system (CNS) tumors are the second most common childhood
malignancy and the most common solid tumor in children. The incidence rate of childhood …
malignancy and the most common solid tumor in children. The incidence rate of childhood …