Central neural regulation of brown adipose tissue thermogenesis and energy expenditure

SF Morrison, CJ Madden, D Tupone - Cell metabolism, 2014 - cell.com
Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic
function of brown adipose tissue (BAT) and contributes to the maintenance of body …

Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease

J Duda, C Pötschke, B Liss - Journal of neurochemistry, 2016 - Wiley Online Library
Dopamine‐releasing neurons within the Substantia nigra (SN DA) are particularly
vulnerable to degeneration compared to other dopaminergic neurons. The age‐dependent …

AgRP neurons control systemic insulin sensitivity via myostatin expression in brown adipose tissue

SM Steculorum, J Ruud, I Karakasilioti, H Backes… - Cell, 2016 - cell.com
Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and
chronically altering their activity also affects peripheral glucose homeostasis. We …

Myeloid-cell-derived VEGF maintains brain glucose uptake and limits cognitive impairment in obesity

A Jais, M Solas, H Backes, B Chaurasia, A Kleinridders… - Cell, 2016 - cell.com
High-fat diet (HFD) feeding induces rapid reprogramming of systemic metabolism. Here, we
demonstrate that HFD feeding of mice downregulates glucose transporter (GLUT)-1 …

[HTML][HTML] Central nervous system regulation of brown adipose tissue

SF Morrison, CJ Madden - Comprehensive Physiology, 2014 - ncbi.nlm.nih.gov
Thermogenesis, the production of heat energy, in brown adipose tissue is a significant
component of the homeostatic repertoire to maintain body temperature during the challenge …

Brain glucose sensing in homeostatic and hedonic regulation

L Steinbusch, G Labouèbe, B Thorens - Trends in Endocrinology & …, 2015 - cell.com
Glucose homeostasis as well as homeostatic and hedonic control of feeding is regulated by
hormonal, neuronal, and nutrient-related cues. Glucose, besides its role as a source of …

Metabolic dysfunction in obstructive sleep apnea: a critical examination of underlying mechanisms

OA Mesarwi, EV Sharma, JC Jun… - Sleep and biological …, 2015 - Springer
It has recently become clear that obstructive sleep apnea (OSA) is an independent risk factor
for the development of metabolic syndrome, a disorder of defective energy storage and use …

Central noradrenaline transporter availability in highly obese, non-depressed individuals

S Hesse, GA Becker, M Rullmann, A Bresch… - European journal of …, 2017 - Springer
Purpose The brain noradrenaline (NA) system plays an important role in the central nervous
control of energy balance and is thus implicated in the pathogenesis of obesity. The specific …

Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis

CG Ardanaz, A de la Cruz, PS Minhas… - Science …, 2024 - science.org
Astrocytes are considered an essential source of blood-borne glucose or its metabolites to
neurons. Nonetheless, the necessity of the main astrocyte glucose transporter, ie, GLUT1 …

[HTML][HTML] Neuronal modulation of brown adipose activity through perturbation of white adipocyte lipogenesis

A Guilherme, DJ Pedersen, F Henriques… - Molecular …, 2018 - Elsevier
Objective Crosstalk between adipocytes and local neurons may be an important regulatory
mechanism to control energy homeostasis. We previously reported that perturbation of …