The pharmacological treatment of urinary incontinence Page 1 BJU International (1999), 84,
923–947 REVIEW The pharmacological treatment of urinary incontinence K.-E …

CONTEXT: Antimuscarinics are the drugs of choice for the treatment of detrusor overactivity
(DO) and overactive bladder (OAB) syndrome. However, the mechanisms for their beneficial …

PURPOSE: Much current research on lower urinary tract physiology focuses on afferent
mechanisms. The main goals are to define and control the signaling pathways by which …

BACKGROUND: Increased nerve growth factor (NGF) levels have been reported in the
bladder tissue and urine of patients with overactive bladder and detrusor overactivity (DO) …

The authors concluded that the evidence did not allow definitive conclusions on the relative
benefit and harm of different treatments to achieve similar results. High-quality research was …

CONTEXT: The focus of clinical understanding and management of male storage lower
urinary tract symptoms (LUTS) has shifted from the prostate to the bladder. This is mirrored …

Background: Antimuscarinic agents used in the treatment of overactive bladder (OAB) differ
in their potential to impair cognitive function. It is hypothesised that low brain concentrations …

Aims To discuss (1) mechanisms involved in the generation and control of myocyte
contractions and consequent afferent nerve activity and (2) these mechanisms as targets for …

Purpose: Typical management of increased bladder storage pressures and decreased
compliance related to neurogenic bladder dysfunction consists of antimuscarinic therapy …

This is a review of the most current literature on medical management of the neurogenic
bladder (NGB) to treat detrusor overactivity (DO), improve bladder compliance and treat …