1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Tremendous advances in understanding the structure and function of the superfamily of
phospholipase A 2 (PLA 2) enzymes has occurred in the twenty-first century. The …

Accumulating evidence over last several years indicates an important role of microglial cells
in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain …

Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

Accumulating evidence suggests that microglial cells in the spinal cord play an important
role in the development of neuropathic pain. However, it remains largely unknown how glia …

Phospholipases A2 (PLA2) are a diverse group of enzymes that hydrolyze membrane
phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is metabolized …

Microsomal prostaglandin E synthase-1 (mPGES-1) is a terminal prostaglandin E2 (PGE2)
synthase in the cyclooxygenase pathway. Inhibitors of mPGES-1 may block PGE2 …

Abstract Phospholipase A 2 (PLA 2) enzymes are involved in various inflammatory
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …

ABSTRACT Phospholipase A2 (PLA2) enzymes are implicated in several pathological
conditions such as arthritis, cardiovascular diseases, and diabetes. It is highly important to …

Traumatic peripheral nerve injury occurs frequently and is a major clinical and public health
problem that can lead to functional impairment and permanent disability. Despite the …