Challenges and advances in clinical applications of mesenchymal stromal cells

T Zhou, Z Yuan, J Weng, D Pei, X Du, C He… - Journal of hematology & …, 2021 - Springer
Mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells, have been
intensely investigated for clinical applications within the last decades. However, the majority …

Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Advances in pluripotent stem cells: history, mechanisms, technologies, and applications

G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Manufacturing of primed mesenchymal stromal cells for therapy

JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …

[HTML][HTML] Secretion of immunoregulatory cytokines by mesenchymal stem cells

D Kyurkchiev, I Bochev… - World journal of stem …, 2014 - ncbi.nlm.nih.gov
According to the minimal criteria of the International Society of Cellular Therapy,
mesenchymal stem cells (MSCs) are a population of undifferentiated cells defined by their …

Identifying the therapeutic significance of mesenchymal stem cells

VK Mishra, HH Shih, F Parveen, D Lenzen, E Ito… - Cells, 2020 - mdpi.com
The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due
to their immense potential for immunosuppression and their therapeutic role in immune …

Mesenchymal stem cell therapy: hope for patients with systemic lupus erythematosus

A Li, F Guo, Q Pan, S Chen, J Chen, H Liu… - Frontiers in …, 2021 - frontiersin.org
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Although previous
studies have demonstrated that SLE is related to the imbalance of cells in the immune …

Preconditioning of human mesenchymal stem cells to enhance their regulation of the immune response

A Saparov, V Ogay, T Nurgozhin… - Stem cells …, 2016 - Wiley Online Library
Mesenchymal stem cells (MSCs) have attracted the attention of researchers and clinicians
for their ability to differentiate into a number of cell types, participate in tissue regeneration …

Pretreated mesenchymal stem cells and their secretome: enhanced immunotherapeutic strategies

Y Su, C Xu, W Cheng, Y Zhao, L Sui… - International journal of …, 2023 - mdpi.com
Mesenchymal stem cells (MSCs) with self-renewing, multilineage differentiation and
immunomodulatory properties, have been extensively studied in the field of regenerative …

[HTML][HTML] Process development for expansion of human mesenchymal stromal cells in a 50 L single-use stirred tank bioreactor

T Lawson, DE Kehoe, AC Schnitzler… - Biochemical …, 2017 - Elsevier
The application of cell-based therapeutics requires development of refined and scalable
culture processes. Stirred tank bioreactors facilitate growth of human mesenchymal stromal …