Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

Endometrial cancer (EC) is one of the most frequently diagnosed cancers in women, and
despite recent therapeutic advances, in many cases, treatment failure results in cancer …

The remarkable regenerative capacity of the endometrium (the inner lining of the uterus) is
essential for the sustenance of mammalian life. Over the years, the role of stem cells in …

The LKB1 tumour suppressor is a serine/threonine kinase that functions as master regulator
of cell growth, metabolism, survival and polarity. LKB1 is frequently mutated in human …

Germline mutations in the gene encoding tumor suppressor kinase LKB1 lead to
gastrointestinal tumorigenesis in Peutz-Jeghers syndrome (PJS) patients and mouse …

Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical
cancer suppressor in many cancer cells. It is a master upstream kinase of 13 AMP-activated …

The epithelial lining of the fallopian tube is vital for fertility, providing nutrition to gametes and
facilitating their transport. It is composed of two major cell types: secretory cells and ciliated …

Although named “ovarian cancer,” it has been unclear whether the cancer actually arises
from the ovary, especially for high-grade serous carcinoma (HGSC), also known as high …

Epithelial ovarian cancer presents mostly with serous, endometrioid or mucinous histology
but is treated as a single disease. The development of histotype-specific therapy has been …

Organoid technology has provided unique insights into human organ development, function,
and diseases. Patient-derived organoids are increasingly used for drug screening, modeling …