Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …

The tremendous rate with which data is generated and analysis methods emerge makes it
increasingly difficult to keep track of their domain of applicability, assumptions, limitations …

Alternative polyadenylation (APA) yields transcripts differing in their 3′-end, and its
regulation is altered in cancer, including prostate cancer. Here we have uncovered a …

Members of the arginine–serine-rich protein family (SR proteins) are multifunctional RNA-
binding proteins that have emerged as key determinants for mRNP formation, identity and …

In countries around the world, sleep deprivation represents a widespread problem affecting
school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep …

This paper concerns 3′-untranslated regions (3′ UTRs) of mRNAs, which are non-coding
regulatory platforms that control stability, fate and the correct spatiotemporal translation of …

Serine/arginine-rich splicing factors (SRSFs) refer to twelve RNA-binding proteins which
regulate splice site recognition and spliceosome assembly during precursor messenger …

Pre-mRNA processing is an essential mechanism for the generation of mature mRNA and
the regulation of gene expression in eukaryotic cells. While defects in pre-mRNA processing …

Nervous system development is associated with extensive regulation of alternative splicing
(AS) and alternative polyadenylation (APA). AS and APA have been extensively studied in …

The mammalian cleavage factor I (CFIm) has been implicated in alternative polyadenylation
(APA) in a broad range of contexts, from cancers to learning deficits and parasite infections …