Antimicrobial peptides as therapeutic agents: Opportunities and challenges

M Mahlapuu, C Björn, J Ekblom - Critical reviews in biotechnology, 2020 - Taylor & Francis
The rapid development of microbial resistance to conventional antibiotics has accelerated
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …

Defining and combating antibiotic resistance from One Health and Global Health perspectives

S Hernando-Amado, TM Coque, F Baquero… - Nature …, 2019 - nature.com
Several interconnected human, animal and environmental habitats can contribute to the
emergence, evolution and spread of antibiotic resistance, and the health of these contiguous …

Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era

J Wang, X Dou, J Song, Y Lyu, X Zhu… - Medicinal research …, 2019 - Wiley Online Library
Antimicrobial peptides (AMPs), critical components of the innate immune system, are widely
distributed throughout the animal and plant kingdoms. They can protect against a broad …

Combating bacterial infections with host defense peptides: shifting focus from bacteria to host immunity

N Gao, J Wang, C Fang, P Bai, Y Sun, W Wu… - Drug Resistance …, 2024 - Elsevier
The increasing prevalence of multidrug-resistant bacterial infections necessitates the
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …

Conditional antimicrobial peptide therapeutics

C Ngambenjawong, LW Chan, HE Fleming… - ACS nano, 2022 - ACS Publications
Antimicrobial peptides (AMPs) constitute a promising class of alternatives to antibiotics to
curb antimicrobial resistance. Nonetheless, their utility as a systemic agent is hampered by …

Antimicrobial and immunomodulatory properties and applications of marine-derived proteins and peptides

HK Kang, HH Lee, CH Seo, Y Park - Marine Drugs, 2019 - mdpi.com
Marine organisms provide an abundant source of potential medicines. Many of the marine-
derived biomaterials have been shown to act as different mechanisms in immune …

Fungal keratitis: Pathogenesis, diagnosis and prevention

L Niu, X Liu, Z Ma, Y Yin, L Sun, L Yang, Y Zheng - Microbial pathogenesis, 2020 - Elsevier
As a kind of serious, potentially sight-threatening corneal infections with poor prognosis,
fungal keratitis can bring a heavy economic burden to patients and seriously affect the …

Designing improved active peptides for therapeutic approaches against infectious diseases

B Gomes, MT Augusto, MR Felício, A Hollmann… - Biotechnology …, 2018 - Elsevier
Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …

[HTML][HTML] Immunomodulatory peptides—A promising source for novel functional food production and drug discovery

M Pavlicevic, N Marmiroli, E Maestri - Peptides, 2022 - Elsevier
Immunomodulatory peptides are a complex class of bioactive peptides that encompasses
substances with different mechanisms of action. Immunomodulatory peptides could also be …

Cysteine‐rich antimicrobial peptides from plants: The future of antimicrobial therapy

S Srivastava, K Dashora, KL Ameta… - Phytotherapy …, 2021 - Wiley Online Library
There has been a spurt in the spread of microbial resistance to antibiotics due to
indiscriminate use of antimicrobial agents in human medicine, agriculture, and animal …