Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy
C Cruz-Teran, K Tiruthani, M McSweeney, A Ma… - Advanced drug delivery …, 2021 - Elsevier
To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …
Intestinal mucus barrier: a missing piece of the puzzle in food allergy
The prevalence of food allergies has reached epidemic levels but the cause remains largely
unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic …
unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic …
Structural alterations of mucins are associated with losses in functionality
M Marczynski, K Jiang, M Blakeley… - …, 2021 - ACS Publications
Commercial mucin glycoproteins are routinely used as a model to investigate the broad
range of important functions mucins fulfill in our bodies, including lubrication, protection …
range of important functions mucins fulfill in our bodies, including lubrication, protection …
Flagella at the host-microbe interface: key functions intersect with redundant responses
DT Akahoshi, CL Bevins - Frontiers in Immunology, 2022 - frontiersin.org
Many bacteria and other microbes achieve locomotion via flagella, which are organelles that
function as a swimming motor. Depending on the environment, flagellar motility can serve a …
function as a swimming motor. Depending on the environment, flagellar motility can serve a …
Targeting the gut microbiota to investigate the mechanism of Lactiplantibacillus plantarum 1201 in negating colitis aggravated by a high-salt diet
S Chen, Z Ren, Y Huo, W Yang, L Peng, H Lv… - Food Research …, 2022 - Elsevier
High-salt diet (HSD) affects the composition and function of the intestinal microbiota and
cause health problems. This study confirmed that HSD aggravates dextran sulphate sodium …
cause health problems. This study confirmed that HSD aggravates dextran sulphate sodium …
Mimicking the gastrointestinal mucus barrier: laboratory-based approaches to facilitate an enhanced understanding of mucus permeation
The gastrointestinal mucus layer plays a significant role in maintaining gut homeostasis and
health, offering protective capacities against the absorption of harmful pathogens as well as …
health, offering protective capacities against the absorption of harmful pathogens as well as …
Recent advances in lipopolysaccharide-based glycoconjugate vaccines
H Zhu, CS Rollier, AJ Pollard - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction The public health burden caused by pathogenic Gram-negative bacteria is
increasingly prominent due to antimicrobial resistance. The surface carbohydrates are …
increasingly prominent due to antimicrobial resistance. The surface carbohydrates are …
The crosstalk between gut bacteria and host immunity in intestinal inflammation
Q Yang, Y Wang, A Jia, Y Wang, Y Bi… - Journal of Cellular …, 2021 - Wiley Online Library
The gut of mammals is considered as a harmonious ecosystem mediated by intestinal
microbiota and the host. Both bacteria and mammalian immune cells show region‐related …
microbiota and the host. Both bacteria and mammalian immune cells show region‐related …
The power of weak, transient interactions across biology: A paradigm of emergent behavior
A growing list of diverse biological systems and their equally diverse functionalities provides
realizations of a paradigm of emergent behavior. In each of these biological systems …
realizations of a paradigm of emergent behavior. In each of these biological systems …
Engineering monoclonal antibody-based contraception and multipurpose prevention technologies
DJ Anderson, JA Politch, RA Cone… - Biology of …, 2020 - academic.oup.com
Sexually transmitted infections are highly prevalent, and over 40% of pregnancies are
unplanned. We are producing new antibody-based multipurpose prevention technology …
unplanned. We are producing new antibody-based multipurpose prevention technology …