Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

C Cruz-Teran, K Tiruthani, M McSweeney, A Ma… - Advanced drug delivery …, 2021 - Elsevier
To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …

Intestinal mucus barrier: a missing piece of the puzzle in food allergy

A Parrish, M Boudaud, A Kuehn, M Ollert… - Trends in Molecular …, 2022 - cell.com
The prevalence of food allergies has reached epidemic levels but the cause remains largely
unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic …

Structural alterations of mucins are associated with losses in functionality

M Marczynski, K Jiang, M Blakeley… - …, 2021 - ACS Publications
Commercial mucin glycoproteins are routinely used as a model to investigate the broad
range of important functions mucins fulfill in our bodies, including lubrication, protection …

Flagella at the host-microbe interface: key functions intersect with redundant responses

DT Akahoshi, CL Bevins - Frontiers in Immunology, 2022 - frontiersin.org
Many bacteria and other microbes achieve locomotion via flagella, which are organelles that
function as a swimming motor. Depending on the environment, flagellar motility can serve a …

Targeting the gut microbiota to investigate the mechanism of Lactiplantibacillus plantarum 1201 in negating colitis aggravated by a high-salt diet

S Chen, Z Ren, Y Huo, W Yang, L Peng, H Lv… - Food Research …, 2022 - Elsevier
High-salt diet (HSD) affects the composition and function of the intestinal microbiota and
cause health problems. This study confirmed that HSD aggravates dextran sulphate sodium …

Mimicking the gastrointestinal mucus barrier: laboratory-based approaches to facilitate an enhanced understanding of mucus permeation

L Wright, P Joyce, TJ Barnes… - ACS biomaterials science …, 2021 - ACS Publications
The gastrointestinal mucus layer plays a significant role in maintaining gut homeostasis and
health, offering protective capacities against the absorption of harmful pathogens as well as …

Recent advances in lipopolysaccharide-based glycoconjugate vaccines

H Zhu, CS Rollier, AJ Pollard - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction The public health burden caused by pathogenic Gram-negative bacteria is
increasingly prominent due to antimicrobial resistance. The surface carbohydrates are …

The crosstalk between gut bacteria and host immunity in intestinal inflammation

Q Yang, Y Wang, A Jia, Y Wang, Y Bi… - Journal of Cellular …, 2021 - Wiley Online Library
The gut of mammals is considered as a harmonious ecosystem mediated by intestinal
microbiota and the host. Both bacteria and mammalian immune cells show region‐related …

The power of weak, transient interactions across biology: A paradigm of emergent behavior

PA Vasquez, B Walker, K Bloom, D Kolbin… - Physica D: Nonlinear …, 2023 - Elsevier
A growing list of diverse biological systems and their equally diverse functionalities provides
realizations of a paradigm of emergent behavior. In each of these biological systems …

Engineering monoclonal antibody-based contraception and multipurpose prevention technologies

DJ Anderson, JA Politch, RA Cone… - Biology of …, 2020 - academic.oup.com
Sexually transmitted infections are highly prevalent, and over 40% of pregnancies are
unplanned. We are producing new antibody-based multipurpose prevention technology …