Implication of cerebral astrocytes in major depression: a review of fine neuroanatomical evidence in humans
LA O'Leary, N Mechawar - Glia, 2021 - Wiley Online Library
Postmortem investigations have implicated astrocytes in many neurological and psychiatric
conditions. Multiple brain regions from individuals with major depressive disorder (MDD) …
conditions. Multiple brain regions from individuals with major depressive disorder (MDD) …
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer's
disease (AD), but little is known about the molecular mechanisms underlying this regional …
disease (AD), but little is known about the molecular mechanisms underlying this regional …
How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders
Severe stress is among the most robust risk factors for the development of psychiatric
disorders. Imaging studies indicate that life stress is integral to shaping the human brain …
disorders. Imaging studies indicate that life stress is integral to shaping the human brain …
Kisspeptin signaling in astrocytes modulates the reproductive axis
E Torres, G Pellegrino, M Granados-Rodríguez… - The Journal of Clinical …, 2024 - jci.org
Reproduction is safeguarded by multiple, often cooperative, regulatory networks. Kisspeptin
signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by …
signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by …
Widespread decrease of cerebral vimentin-immunoreactive astrocytes in depressed suicides
LA O'Leary, C Belliveau, MA Davoli, JC Ma… - Frontiers in …, 2021 - frontiersin.org
Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for
glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide. However …
glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide. However …
Ion channel drugs suppress cancer phenotype in NG108-15 and U87 cells: toward novel electroceuticals for glioblastoma
Simple Summary Glioblastoma is a rapidly progressing brain cancer that is very difficult to
treat. Given that many aspects of cell and tissue behavior are controlled by electric signaling …
treat. Given that many aspects of cell and tissue behavior are controlled by electric signaling …
Radial stem astrocytes (aka neural stem cells): identity, development, physio‐pathology, and therapeutic potential
CY Yeh, KY Wu, GJ Huang, A Verkhratsky - Acta Physiologica, 2023 - Wiley Online Library
Adult neurogenesis is a striking example of neuroplasticity, which enables adaptive network
remodelling in response to all forms of environmental stimulation in physiological and …
remodelling in response to all forms of environmental stimulation in physiological and …
Astroglial connexin 43-mediated gap junctions and hemichannels: potential antidepressant mechanisms and the link to neuroinflammation
L Lei, YT Wang, D Hu, C Gai, Y Zhang - Cellular and Molecular …, 2023 - Springer
Major depression disorder (MDD) is a neuropsychiatric disorder associated with a high
suicide rate and a higher disability rate than any other disease. Evidence suggests that the …
suicide rate and a higher disability rate than any other disease. Evidence suggests that the …
Gene enrichment analysis of astrocyte subtypes in psychiatric disorders and psychotropic medication datasets
Astrocytes have many important functions in the brain, but their roles in psychiatric disorders
and their responses to psychotropic medications are still being elucidated. Here, we used …
and their responses to psychotropic medications are still being elucidated. Here, we used …
Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer's disease
Plasma glial fibrillary acidic protein (GFAP) is an emerging biomarker of Alzheimer's disease
(AD), with higher blood GFAP levels linked to faster cognitive decline, particularly among …
(AD), with higher blood GFAP levels linked to faster cognitive decline, particularly among …