Implication of cerebral astrocytes in major depression: a review of fine neuroanatomical evidence in humans

LA O'Leary, N Mechawar - Glia, 2021 - Wiley Online Library
Postmortem investigations have implicated astrocytes in many neurological and psychiatric
conditions. Multiple brain regions from individuals with major depressive disorder (MDD) …

Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease

S Chen, Y Chang, L Li, D Acosta, Y Li, Q Guo… - Acta Neuropathologica …, 2022 - Springer
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer's
disease (AD), but little is known about the molecular mechanisms underlying this regional …

How stress physically re-shapes the brain: Impact on brain cell shapes, numbers and connections in psychiatric disorders

D Kaul, SG Schwab, N Mechawar, N Matosin - … & Biobehavioral Reviews, 2021 - Elsevier
Severe stress is among the most robust risk factors for the development of psychiatric
disorders. Imaging studies indicate that life stress is integral to shaping the human brain …

Kisspeptin signaling in astrocytes modulates the reproductive axis

E Torres, G Pellegrino, M Granados-Rodríguez… - The Journal of Clinical …, 2024 - jci.org
Reproduction is safeguarded by multiple, often cooperative, regulatory networks. Kisspeptin
signaling, via KISS1R, plays a fundamental role in reproductive control, primarily by …

Widespread decrease of cerebral vimentin-immunoreactive astrocytes in depressed suicides

LA O'Leary, C Belliveau, MA Davoli, JC Ma… - Frontiers in …, 2021 - frontiersin.org
Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for
glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide. However …

Ion channel drugs suppress cancer phenotype in NG108-15 and U87 cells: toward novel electroceuticals for glioblastoma

J Mathews, F Kuchling, D Baez-Nieto, M Diberardinis… - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma is a rapidly progressing brain cancer that is very difficult to
treat. Given that many aspects of cell and tissue behavior are controlled by electric signaling …

Radial stem astrocytes (aka neural stem cells): identity, development, physio‐pathology, and therapeutic potential

CY Yeh, KY Wu, GJ Huang, A Verkhratsky - Acta Physiologica, 2023 - Wiley Online Library
Adult neurogenesis is a striking example of neuroplasticity, which enables adaptive network
remodelling in response to all forms of environmental stimulation in physiological and …

Astroglial connexin 43-mediated gap junctions and hemichannels: potential antidepressant mechanisms and the link to neuroinflammation

L Lei, YT Wang, D Hu, C Gai, Y Zhang - Cellular and Molecular …, 2023 - Springer
Major depression disorder (MDD) is a neuropsychiatric disorder associated with a high
suicide rate and a higher disability rate than any other disease. Evidence suggests that the …

Gene enrichment analysis of astrocyte subtypes in psychiatric disorders and psychotropic medication datasets

X Zhang, A Wolfinger, X Wu, R Alnafisah, A Imami… - Cells, 2022 - mdpi.com
Astrocytes have many important functions in the brain, but their roles in psychiatric disorders
and their responses to psychotropic medications are still being elucidated. Here, we used …

Pathologic and clinical correlates of region-specific brain GFAP in Alzheimer's disease

JM Phillips, RL Winfree, M Seto, JA Schneider… - Acta …, 2024 - Springer
Plasma glial fibrillary acidic protein (GFAP) is an emerging biomarker of Alzheimer's disease
(AD), with higher blood GFAP levels linked to faster cognitive decline, particularly among …