Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …

The crosstalk between endothelial cells and cardiomyocytes has emerged as a requisite for
normal cardiac development, but also a key pathogenic player during the onset and …

Sarcopenia, the degenerative loss of skeletal muscle mass, quality and strength, lacks early
diagnostic tools and new therapeutic strategies to prevent the frailty-to-disability transition …

Vascular dysfunction is a hallmark of chronic diseases in elderly. The contribution of the
vasculature to lung repair and fibrosis is not fully understood. Here, we performed an …

Aims Exercise confers protection against cardiovascular ageing, but the mechanisms remain
largely unknown. This study sought to investigate the role of fibronectin type-III domain …

Physical activity has been found to aid the maintenance of health in the elderly. Exercise-
induced skeletal muscle contractions lead to the production and secretion of many small …

Aging is characterized by the progressive dysfunction of most tissues and organs, which has
been linked to the regenerative decline of their resident stem cells over time. Skeletal …

It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs
and secrete in normal and in pathological conditions several molecules, called, respectively …

Adult stem cells sustain tissue homeostasis and regeneration; their functional decline is
often linked to aging, which is characterized by the progressive loss of physiological …

The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological
roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are …