Bacterial chromosomes are folded to compact DNA and facilitate cellular processes.
Studying model bacteria has revealed aspects of chromosome folding that are applicable to …

It has been over 20 years since the pioneering work of Arthur Ashkin, and in the intervening
years, the field of optical tweezers has grown tremendously. Optical tweezers are now being …

Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Horizontal gene transfer plays a major role in microbial evolution. However, newly acquired
sequences can decrease fitness unless integrated into preexisting regulatory networks. We …

How genomes are organized within cells and how the 3D architecture of a genome
influences cellular functions are significant questions in biology. A bacterial genomic DNA …

The effect of the bacterial heat-stable nucleoid-structuring (H-NS) protein on gene
expression is overwhelmingly negative and extends throughout the genome, pointing to an …

Spatial organization is a hallmark of all living systems. Even bacteria, the smallest forms of
cellular life, display defined shapes and complex internal organization, showcasing a highly …

The bacterial chromosomal DNA is folded into a compact structure called nucleoid. The
shape and size of this 'body'is determined by a number of factors. Major players are DNA …

Both prokaryotic and eukaryotic organisms contain DNA bridging proteins, which can have
regulatory or architectural functions. The molecular and mechanical details of such proteins …

Cellular DNA is continuously engaged in a molecular dance with many accessory proteins.
These proteins are responsible for orchestrating the storage, maintenance, and transfer of …