Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment

J Choi, IC Sun, HS Hwang, HY Yoon, K Kim - Advanced Drug Delivery …, 2022 - Elsevier
Photodynamic nanomedicines have significantly enhanced the therapeutic efficacy of
photosensitizers (PSs) by overcoming critical limitations of PSs such as poor water solubility …

Recent progress in multifunctional conjugated polymer nanomaterial-based synergistic combination phototherapy for microbial infection theranostics

P Manivasagan, J Kim, ES Jang - Coordination Chemistry Reviews, 2022 - Elsevier
Microbial infection is a critical public health problem, owing to its strong infectivity and high
risk of mortality. Multi-antibiotic resistant pathogens reduce the efficacy of commercial …

Enzyme-responsive double-locked photodynamic molecular beacon for targeted photodynamic anticancer therapy

LKB Tam, JCH Chu, L He, C Yang… - Journal of the …, 2023 - ACS Publications
An advanced photodynamic molecular beacon (PMB) was designed and synthesized, in
which a distyryl boron dipyrromethene (DSBDP)-based photosensitizer and a Black Hole …

Specific activation of photosensitizer with extrinsic enzyme for precisive photodynamic therapy

J Xiong, JCH Chu, WP Fong, CTT Wong… - Journal of the …, 2022 - ACS Publications
Delivery of functional proteins into the intracellular space has been a challenging task that
could lead to a myriad of therapeutic applications. We report herein a novel bioconjugation …

Trial watch: an update of clinical advances in photodynamic therapy and its immunoadjuvant properties for cancer treatment

M Penetra, LG Arnaut, LC Gomes-da-Silva - 2023 - Taylor & Francis
Photodynamic therapy (PDT) is a medical treatment used to target solid tumors, where the
administration of a photosensitizing agent and light generate reactive oxygen species …

EGFR-targeted photodynamic therapy

L Ulfo, PE Costantini, M Di Giosia, A Danielli… - Pharmaceutics, 2022 - mdpi.com
The epidermal growth factor receptor (EGFR) plays a pivotal role in the proliferation and
metastatization of cancer cells. Aberrancies in the expression and activation of EGFR are …

Design and Development of a Bioorthogonal, Visualizable and Mitochondria‐Targeted Hydrogen Sulfide (H2S) Delivery System

Y Chen, R Zhao, C Tang, C Zhang, W Xu… - Angewandte …, 2022 - Wiley Online Library
Hydrogen sulfide (H2S) is an important endogenous gasotransmitter, but the targeted
delivery and real‐time feedback of exogenous H2S are still challenging. With the aid of …

Gel formulations for topical treatment of skin cancer: a review

M Slavkova, B Tzankov, T Popova, C Voycheva - Gels, 2023 - mdpi.com
Skin cancer, with all its variations, is the most common type of cancer worldwide.
Chemotherapy by topical application is an attractive strategy because of the ease of …

Unraveling the pivotal role of atropisomerism for cellular internalization

C Donohoe, FA Schaberle… - Journal of the …, 2022 - ACS Publications
The intrinsic challenge of large molecules to cross the cell membrane and reach intracellular
targets is a major obstacle for the development of new medicines. We report how rotation …

Combinatorial therapeutic approaches with nanomaterial-based photodynamic cancer therapy

Y Hao, CK Chung, Z Yu, RV Huis in 't Veld… - Pharmaceutics, 2022 - mdpi.com
Photodynamic therapy (PDT), in which a light source is used in combination with a
photosensitizer to induce local cell death, has shown great promise in therapeutically …