Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Chiral amino acids are extensively applied in the pharmaceutical, food, cosmetic,
agricultural, and feedstuff industries. The development of synthetic methodologies for …

Life is constructed primarily using a toolbox of 20 canonical amino acids─ relying upon
these building blocks for the assembly of proteins and peptides that regulate nearly every …

Carbon–carbon bond formation is the key reaction for organic synthesis to construct the
carbon framework of organic molecules. The review gives a selection of biocatalytic C–C …

Lyases are enzymes that catalyze the bond construction and breaking by means other than
hydrolysis or redox reactions. Such enzymes are particular in the sense that they only …

Aldol reactions constitute a powerful methodology for carbon–carbon bond formation in
synthetic organic chemistry. Biocatalysis by means of aldolases offers a unique …

Carbon‐carbon bond formation is among the most challenging transformations in the
organic synthetic chemistry. Enzymes capable to perform this reaction are of great interest …

The direct asymmetric aldol reaction of glycinates represents an intriguing and
straightforward strategy to make biologically significant chiral β‐hydroxy‐α‐amino‐acid …

l-Threonine transaldolase (LTTA) is an attractive biocatalyst because of its potential
diastereoselectivity in the synthesis of β-hydroxy-α-amino acids (βHAAs). However …

Threonine aldolases have emerged as a powerful tool for asymmetric carbon-carbon bond
formation. These enzymes catalyse the unnatural aldol condensation of different aldehydes …