Thalamocortical circuits in generalized epilepsy: Pathophysiologic mechanisms and therapeutic targets
Generalized epilepsy affects 24 million people globally; at least 25% of cases remain
medically refractory. The thalamus, with widespread connections throughout the brain, plays …
medically refractory. The thalamus, with widespread connections throughout the brain, plays …
Alpha2-adrenergic receptors as a pharmacological target for spike-wave epilepsy
E Sitnikova, E Rutskova, K Smirnov - International journal of molecular …, 2023 - mdpi.com
Spike-wave discharges are the hallmark of idiopathic generalized epilepsy. They are
caused by a disorder in the thalamocortical network. Commercially available anti-epileptic …
caused by a disorder in the thalamocortical network. Commercially available anti-epileptic …
[HTML][HTML] Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension …
CY Ho, GC Sun, YT Lin, TY Wong, M Hsiao… - European Journal of …, 2024 - Elsevier
Our previous study reported that the heterodimer of Angiotensin II Type I Receptor (AT1R)
and Mu-Opioid Receptor 1 (MOR1) involves Nitric Oxide (NO) reduction which leads to …
and Mu-Opioid Receptor 1 (MOR1) involves Nitric Oxide (NO) reduction which leads to …
Respiratory brain impulse propagation in focal epilepsy
Respiratory brain pulsations pertaining to intra-axial hydrodynamic solute transport are
markedly altered in focal epilepsy. We used optical flow analysis of ultra-fast functional …
markedly altered in focal epilepsy. We used optical flow analysis of ultra-fast functional …
[HTML][HTML] Higher-order thalamic nuclei facilitate the generalization and maintenance of spike-and-wave discharges of absence seizures
Z Atherton, O Nagy, L Barcsai, P Sere, N Zsigri… - Neurobiology of …, 2023 - Elsevier
Spike-and-wave discharges (SWDs), generated by the cortico-thalamo-cortical (CTC)
network, are pathological, large amplitude oscillations and the hallmark of absence seizures …
network, are pathological, large amplitude oscillations and the hallmark of absence seizures …
Adrenergic mechanisms of absence status epilepticus
E Sitnikova - Frontiers in Neurology, 2023 - frontiersin.org
Absence status epilepticus is a prolonged, generalized absence seizure that lasts more than
half an hour. The mechanisms underlying the absence of status epilepticus are still not …
half an hour. The mechanisms underlying the absence of status epilepticus are still not …
Attenuating midline thalamus bursting to mitigate absence epilepsy
Advancing the mechanistic understanding of absence epilepsy is crucial for developing new
therapeutics, especially for patients unresponsive to current treatments. Utilizing a recently …
therapeutics, especially for patients unresponsive to current treatments. Utilizing a recently …
Heartbeat-evoked potentials following voluntary hyperventilation in epilepsy patients: respiratory influences on cardiac interoception
Introduction Current evidence indicates a modulating role of respiratory processes in cardiac
interoception, yet whether altered breathing patterns influence heartbeat-evoked potentials …
interoception, yet whether altered breathing patterns influence heartbeat-evoked potentials …
The respiratory cycle modulates distinct dynamics of affective and perceptual decision-making
Respiratory rhythms play a critical role not only in homeostatic survival, but also in
modulating other non-interoceptive perceptual and affective processes. Recent evidence …
modulating other non-interoceptive perceptual and affective processes. Recent evidence …
Respiratory modulations of cortical excitability and interictal spike timing in focal epilepsy-a case report
Brain activity in focal epilepsy is marked by a pronounced excitation-inhibition (E: I)
imbalance and interictal epileptiform discharges (IEDs) observed in periods between …
imbalance and interictal epileptiform discharges (IEDs) observed in periods between …