For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …

Fatty acid synthase (FAS) catalyzes the de novo synthesis of fatty acids. In the liver, FAS has
long been categorized as a housekeeping protein, producing fat for storage of energy when …

Recent advances in technology have led to a dramatic increase in the number of available
transcription factor ChIP-seq and ChIP-chip data sets. Understanding the motif content of …

Chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq) has
become the dominant technique for mapping transcription factor (TF) binding regions …

Transcription factors bind DNA by recognizing specific sequence motifs, which are typically
6–12 bp long. A motif can occur many thousands of times in the human genome, but only a …

The CCAAT box promoter element and NF-Y, the transcription factor (TF) that binds to it,
were among the first cis-elements and trans-acting factors identified; their interplay is …

Estrogen receptor-α (ERα) is a ligand-activated transcription factor and a member of the
nuclear receptor superfamily. The classic mechanism of (ERα) action is associated with …

The multidrug resistance (MDR) phenotype is the major cause of failure of cancer
chemotherapy. This phenotype is mainly due to the overexpression of the human MDR1 …

The enhanced synthesis of fatty acids in the liver and adipose tissue in response to insulin is
critically dependent on the transcription factor SREBP-1c (sterol-regulatory-element-binding …

The MDR1 promoter is subject to control by various internal and external stimuli. We have
previously shown that the CCAAT box-binding protein, NF-Y, mediates MDR1 activation by …